Prevalence of dumping after bariatric surgery

Hyperinsulinemic hypoglycemia, satiety and other blood parameters during a Mixed Meal Tolerance Test in patients after gastric bypass surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN11738149

Enrollment

Registered

2017-08-03

Start date

2013-02-01

Completion date

Unknown

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperinsulinemic hypoglycaemia, nesidioblastosis, late dumping, satiety, metabolism Nutritional, Metabolic, Endocrine

Interventions

After an overnight fast, all subjects will undergo a Mixed Meal Tolerance Test (MMTT) consisting of 200mL Ensure® Plus (Abbott Laboratories, North Chicago, IL, USA) containing 300 kcal, 12.5 g protein

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who underwent primary Roux-en-Y gastric bypass surgery between 2008 and 2011 2. Age between 18 and 75 years 3. Informed consent

Exclusion criteria

Exclusion criteria: Patients with diabetes mellitus

Design outcomes

Primary

Measure	Time frame
The prevalence of hyperinsulinemic hypoglycemia after gastric bypass during a 3.5 hour Mixed Meal Tolerance Test (MMTT). Symptoms will be assessed by the Dumping Severity Score and other questionnaires every 30 minutes and blood collection will be performed at baseline and 10, 20, 30, 60, 90, 120, 150, 180 and 210 minutes after the start of the test meal.	—

Secondary

Measure	Time frame
1. Sensitivity and specificity of the Dumping Severity Score and other questionnaires for early and late dumping assessed every 30 minutes during the 3.5 hour MMTT 2. Plasma incretin (i.e., gastrointestinal hormone) concentrations during the 3.5 hour MMTT with blood collection at baseline and 10, 20, 30, 60, 90, 120, 150, 180 and 210 minutes after the start of the test meal 3. Plasma amino acid concentrations during the 3.5 hour MMTT with blood collection at baseline and 10, 20, 30, 60, 90, 120, 150, 180 and 210 minutes after the start of the test meal 4. Other blood parameters during the 3.5 hour MMTT with blood collection at baseline and 10, 20, 30, 60, 90, 120, 150, 180 and 210 minutes after the start of the test meal 5. Satiety scores, measured every 30 minutes using a visual analogue scale (VAS) during the 3.5 hour MMTT	—

Measure

Time frame

1. Sensitivity and specificity of the Dumping Severity Score and other questionnaires for early and late dumping assessed every 30 minutes during the 3.5 hour MMTT 2. Plasma incretin (i.e., gastrointestinal hormone) concentrations during the 3.5 hour MMTT with blood collection at baseline and 10, 20, 30, 60, 90, 120, 150, 180 and 210 minutes after the start of the test meal 3. Plasma amino acid concentrations during the 3.5 hour MMTT with blood collection at baseline and 10, 20, 30, 60, 90, 120, 150, 180 and 210 minutes after the start of the test meal 4. Other blood parameters during the 3.5 hour MMTT with blood collection at baseline and 10, 20, 30, 60, 90, 120, 150, 180 and 210 minutes after the start of the test meal 5. Satiety scores, measured every 30 minutes using a visual analogue scale (VAS) during the 3.5 hour MMTT

—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026