Prediction of acute and post-recovery outcomes in paediatric cerebral malaria Infections and Infestations
Conditions
Interventions
This is a cohort study to determine if an imaging device can differentiate different groups within the cohort (severe brain swelling versus no/mild/moderate brain swelling
and in follow-up, neurodevelopmental deficit versus none). There is no randomisation or intervention. Some controls are being recruited in order to determine normal child development in this populatio
Sponsors
University of Liverpool
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Parent or guardian gives informed consent for their child’s participation 2. Cerebral malaria: under 16 years of age, BCS=2, Plasmodium falciparum parasitaemia on a blood film, no other cause of coma evident 3. Other comas: under 16 years of age, BCS=3 with acute presentation. 4. Healthy controls age-matched under 16 years
Exclusion criteria
Exclusion criteria: 1. Hypoglycaemia, post-ictal, or other transient state accounting for coma 2. Contraindication to MRI 3. History or evidence of pre-existing hydrocephalus, significant neurological disease, gross neurological disability or learning difficulties 4. History or evidence of pre-existing significant ocular disease 5. History or evidence of severe life-limiting or chronic disease including but not limited to advanced HIV/AIDS (Stage 4), disseminated TB and malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic nerve head (ONH) swelling measured using optical coherence tomography (OCT) at admission, then daily during admission | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Macular ischaemia measured using OCT at admission, then daily during admission 2. Acceptability of novel OCT measured using a 5-point scale at each use 3. Effectiveness of novel OCT measured using intraclass correlation coefficients during data analysis | — |
Countries
Malawi
Outcome results
None listed