Haemodialysis, kidney failure Urological and Genital Diseases Renal failure
Conditions
Interventions
Participants will be randomised to either:
1. Intervention arm where participants will receive 6 - 8 h of in-centre haemodialysis delivered overnight, 3 times per week for 6 months.
2. Standard care a
Sponsors
University of Leicester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Participant in the main NightLife study (ISRCTN87042063) 2. Patients established on haemodialysis for =3 months (i.e. prevalent dialysis patients) 3. Aged =18 years 4. Able to give informed consent 5. Able to participate fully in the interventions and follow-up procedures
Exclusion criteria
Exclusion criteria: 1. Currently on in-centre nocturnal dialysis, or less than 3 months since stopping 2. Less than 3 months since stopping extended daytime dialysis 3. Patients for whom extended dialysis is clinically indicated (e.g. calciphylaxis, pregnancy) 4. Scheduled for living donor kidney transplant 5. Plan to change dialysis modality or centre in the next 6-months 6. Life expectancy of <6-months 7. Current participation in an interventional trial with conflicting therapies or primary outcomes 8. Absolute contraindications to a cardiac MRI scan (CMR): non-conditional devices or implants; severe claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global myocardial native T1 time measured by cardiac MRI at baseline and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Other prognostically powerful measures of cardiovascular disease assessed with cardiac MRI at baseline and 6 months 1.1. Left ventricular mass, volumes and ejection fraction 1.2. Peak systolic circumferential and longitudinal strain and early diastolic strain rates 1.3. Aortic stiffness assessed with aortic distensibility and aortic pulse wave velocity 1.4. Native T2 mapping 2. Myocardial fibriosis measured using blood test for high-sensitivity cardiac Troponin I, taken at the beginning and ends of dialysis sessions, at baseline and 6 months | — |
Countries
England, Scotland, United Kingdom
Outcome results
None listed