Can using two types of lasers together make burn scars look and feel better compared to usual care?

Combined Laser Improves Scar Outcome (CLIPSO): A feasibility study assessing combined pulsed dye and fractional carbon dioxide laser on burn scar outcomes versus standard care

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11703740

Enrollment

Registered

2023-09-11

Start date

2023-10-01

Completion date

Unknown

Last updated

2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burns and corrosions of multiple and unspecified body regions Injury, Occupational Diseases, Poisoning

Interventions

Each participant will be randomised to one of three groups at first visit

COMBINED LASER (CL) - 10 participants SINGLE LASER (SL) - 10 participants CONTROL (C) - 10 participants A single scar site =1% TBSA is required for each patient. In the event that the patient has mul

for low volume scars or where patients do not wish for laser treatment elsewhere on their body, topical anaesthesia will be chosen. No participants will receive general or regional anaesthesia solely

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participants > 18 years of age 2. Hypertrophic burn scar > = 1% TBSA 3. Scars which would ordinarily be managed by pressure garments and laser intervention 4. All patients to be less than 3 months from burn injury at point of recruitment.

Exclusion criteria

Exclusion criteria: 1. Participants < 18 years of age 2. Pregnant or breast feeding females 3. Facial scars 4. Keloid scars 5. Hypertrophic scars of non-burn aetiology 6. Mature (pale) scars more than 18 months from time of injury 7. Inability to give informed consent 8. Systemic glucocorticoid use 9. Previous topical or intralesional steroid treatment to study scar 10. Fitzpatrick skin types 4 - 6 11. Non-English speaking

Design outcomes

Primary

Measure	Time frame
1. Subjective scar assessment using Patient Observer Scar Score (POSAS) and Brisbane Burn Scar Impact Profile (BBSIP) at baseline, 4 months and 8 months. 2. Objective scar assessment using Manchester scar score, Patient Observer Scar Score (POSAS) and colorimetry at baseline, 4 months and 8 months.	—

Secondary

Measure	Time frame
1. Subjective itch assessment using Patient Observer Scar Score (POSAS) and Brisbane Burn Scar Impact Profile (BBSIP) at baseline, 4 months and 8 months. 2. Assessment of psychological scar impact using Patient Observer Scar Score (POSAS) and Brisbane Burn Scar Impact Profile (BBSIP) at baseline, 4 months and 8 months.	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026