Effects of wholegrain-derived compounds supplementation on blood vessel stiffness

The effects of short chain fatty acid supplementation on vascular function in middle-aged volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11698069

Enrollment

Registered

2016-04-04

Start date

2016-01-14

Completion date

Unknown

Last updated

2021-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood pressure Circulatory System Blood pressure

Interventions

Participants receive the intervention and control treatment in a random order, which are delivered at separate study visits (2-4 weeks apart). Before the study visit, participants are asked to refrain

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Male 2. Aged 40-65 years old 3. 115mmHg = systolic blood pressure =159mmHg & 70mmHg = diastolic blood pressure = 99mmHg 4. BMI between 19 and 30 kg/m2

Exclusion criteria

Exclusion criteria: 1. BMI under 19 kg/m2 or over 30kg/m2 2. Systolic blood pressure >159mmHg or <115mmHg & diastolic blood pressure 3. Any pharmalogical treatment for hypertension or depression 4. Suffering from eating disorders and/or taking any nutritional supplements, and/or usually eating high intake of wholegrains or probiotics

Design outcomes

Primary

Measure	Time frame
Arterial function measured by pulse wave analysis	—

Secondary

Measure	Time frame
1. Blood pressure measured using the 24 hour blood pressure monitor over the 24 hours following each of the two study visits 2. Systemic markers of endothelial function 3. Blood pressure regulation	—

Countries

United Kingdom

Contacts

Public ContactKarolin Muzs

karolin.muzs@abdn.ac.uk+44 (0)1224 438758

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026