Effects of intravenous lidocaine on somatosensory and motor evoked potentials during spine surgery

In patients undergoing multilevel posterior spinal fusion, does the addition of intravenous lidocaine as a component of balanced anesthesia, compared to balanced anesthesia without lidocaine, alter somatosensory and motor evoked potentials?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11684890

Enrollment

Registered

2017-01-13

Start date

2012-03-28

Completion date

Unknown

Last updated

2017-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multilevel posterior spinal fusion Musculoskeletal Diseases Multilevel posterior spinal fusion

Interventions

Each study patient alternately receives two anesthetic treatments. The order of administration is determined randomly. The treatments are propofol at 50 mcg/kg/h, or propofol 25 mcg/kg/min + lidocaine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients undergoing multi-level posterior spine fusions requiring both somatosensory and motor evoked potential monitoring 2. Ages within the age range of 18 – 70 years.

Exclusion criteria

Exclusion criteria: 1. Allergy to any of the anesthetic medications included in the protocol 2. Current use of medication for Parkinson’s disease 3. Current psychotropic medication 4. History of cardiac arrhythmias 5. Non-English speaking

Design outcomes

Primary

Measure	Time frame
1. Somatosensory evoked potential amplitude is measured using a Cadwell Elite intraoperative monitoring system, at 3-5 minute intervals 2. Motor evoked potentials threshold voltage is measured using a Cadwell Elite intraoperative monitoring system, at 10-20 minute intervals	—

Secondary

Measure	Time frame
1. Isoflurane concentration is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals 2. Heart rate is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals 3. Blood pressure is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals 4. Temperature is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals 5. Estimated blood loss is measured at the conclusion of the procedure based on cell salvage system data, irrigation and intraoperative blood administration	—

Measure

Time frame

1. Isoflurane concentration is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals 2. Heart rate is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals 3. Blood pressure is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals 4. Temperature is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals 5. Estimated blood loss is measured at the conclusion of the procedure based on cell salvage system data, irrigation and intraoperative blood administration

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Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026