SEARCH: Screening for early detection of second lung cancer after radiotherapy or chemotherapy for Hodgkin lymphoma

SEARCH: Screening for Early detection of second cancers After Radiotherapy and Chemotherapy for Hodgkin lymphoma . Implementing and evaluating lung cancer screening for high-risk Hodgkin lymphoma survivors within the NHS national lung cancer screening programme

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11668189

Enrollment

4400

Registered

2026-03-30

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung cancer risk among survivors of classical Hodgkin lymphoma Cancer

Interventions

SEARCH is a multicentre, pragmatic, real-world evaluation study integrating a risk-adapted lung cancer screening pathway for high-risk Hodgkin lymphoma (HL) survivors within the NHS Lung Cancer Screen

Eligibility

Sex/Gender

All

Age

45 Years to 74 Years

Inclusion criteria

Inclusion criteria: 1. Previous classical Hodgkin lymphoma treated with chemotherapy ± radiotherapy; no relapse or HL treatment within the past 3 years 2. Age 45–74 years at identification. 3. Ever-smoker (current or former), with smoking history verified (typically =100 lifetime cigarettes or equivalent). 4. Able to undergo LDCT, including ability to lie flat and weight =200 kg 5. Medically fit for potential curative-intent lung cancer treatment (i.e., not severely frail and not on palliative care pathways). 6. Capacity to give informed consent 7. Individuals with a prior thoracic CT within 24 months may participate if imaging meets study standards (still complete LHC, risk assessment, ePRO, etc.)

Exclusion criteria

Exclusion criteria: 1. Never-smokers: Individuals with no history of ever smoking 2. Lack of capacity to consent: Unable to provide informed consent at the time of enrolment 3. Incorrect lymphoma diagnosis: Any lymphoma other than classical Hodgkin lymphoma 4. History of lung cancer =24 months previously: Participants with a diagnosis of lung cancer occurring =24 months prior to identification 5. Unsuitable for LDCT scanning. Including: 5.1. Weight >200 kg 5.2. Unable to lie flat 5.3. Any physical, clinical, or technical contraindication preventing LDCT acquisition 6. Not medically fit for curative-intent treatment. Including: 6.1. Severe frailty (eFI >0.36) 6.2. Registered on a palliative care register 6.3. Metastatic cancer with poor prognosis 6.4. Any comorbidity making curative treatment inappropriate 7. Self-referrals from outside England: Individuals self-referring from outside England are not eligible

Countries

England, United Kingdom

Contacts

Public ContactTania Seale

tania.seale@manchester.ac.uk+44 7879779259

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 17, 2026