A randomised controlled trial investigating the effects of compression stockings in patients who require blood thinning medication post discharge from elective surgery

Graduated compression stocking as an adjunct to extended duration pharmacological thromboprophylaxis for venous thromboembolism prevention

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11667770

Enrollment

4696

Registered

2023-12-18

Start date

2024-05-01

Completion date

Unknown

Last updated

2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Venous thromboembolism Circulatory System

Interventions

Baseline Visit (Visit 0): Consenting participants will be randomised in a 1:1 fashion to one of two thromboprophylaxis strategies: 1. Extended duration pharmacological thromboprophylaxis (EDPTP)* in a

Eligibility

Sex/Gender

All

Age

18 Years to 120 Years

Inclusion criteria

Inclusion criteria: 1. Adults (>18 years) 2. Participants undergoing elective surgery; risk assessed as requiring EDPTP. Participants are deemed to require extended duration thromboprophylaxis measures as per local policy in line with NICE [NG89] guidelines. Examples of procedures from which patients are at the highest risk of VTE include (but are not limited to): orthopaedic surgery (total hip replacement, total knee replacement, colorectal surgery (colectomy, splenectomy), upper gastrointestinal surgery (oesophagectomy, gastrectomy), urological surgery (cystectomy, nephrectomy), and gynaecological oncology surgery (radical hysterectomy, radical trachelectomy).

Exclusion criteria

Exclusion criteria: 1. Contraindications to EDPTP or GCS 2. Individuals requiring therapeutic anticoagulation e.g., anticoagulation for previous DVT 3. Known thrombophilia or thrombogenic disorder

Design outcomes

Primary

Measure	Time frame
Imaging-confirmed lower limb DVT with or without symptoms, or PE with symptoms, occurring up to 90 days post-surgery	—

Secondary

Measure	Time frame
Defined as occurring within 90 days of surgery: 1. Mortality recorded within 90 days 2. Adverse events related to GCS recorded within 90 days 3. Adherence with GCS, defined as (percentage of actual days worn / maximum number of days prescribed according to local practice) 4. Adherence with EDPTP, defined as (percentage of actual days taken / maximum number of days prescribed, according to local practice) 5. Safety outcome measures, defined as major bleeding events recorded within 90 days	—

Measure

Time frame

Defined as occurring within 90 days of surgery: 1. Mortality recorded within 90 days 2. Adverse events related to GCS recorded within 90 days 3. Adherence with GCS, defined as (percentage of actual days worn / maximum number of days prescribed according to local practice) 4. Adherence with EDPTP, defined as (percentage of actual days taken / maximum number of days prescribed, according to local practice) 5. Safety outcome measures, defined as major bleeding events recorded within 90 days

—

Countries

England, United Kingdom

Contacts

Public ContactFrancine Heatley

f.heatley@imperial.ac.uk-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 21, 2026