Omega-3 metabolism Nutritional, Metabolic, Endocrine Omega-3 metabolism
Conditions
Interventions
Participants will be allocated to one of the following groups:
1. Omega-3 ethyl esters
2. Omega-3 free fatty acids
3. Omega-3 triglycerides (standard fo
Sponsors
University Hospital Southampton NHS Foundation Trust
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Male 2. Aged 18 to 45 years 3. In general good health 4. Body mass index between 20 and 32 kg/m2 5. Not consuming fish oil or other oil supplements 6. Not eating more than one oily fish meal per week 7. Willing to adhere to the study protocol 8. Being able to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Female 2. Aged under 18 or over 45 years 3. Body mass index less than 20 or more than 32 kg/m2 4. Being diabetic (type 1 or type 2) 5. Use of prescribed medicine to control inflammation 6. Chronic gastrointestinal problems (e.g. IBD, IBS, celiac disease, cancer) 7. Participation in another clinical trial 8. Use of fish oil or other oil supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in EPA and DHA contents of plasma phospholipids is measured using blood testing at baseline (immediately before the meal) and 0.5, 1, 1.5, 2, 2.5, 3, 4, 5 and 6 hours after consuming the meal | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in EPA content of plasma triglycerides, cholesteryl esters and non-esterified fatty acids, and erythrocytes and mononuclear cells over 6 hours 2. Change in DHA content of plasma triglycerides, cholesteryl esters and non-esterified fatty acids, and erythrocytes and mononuclear cells over 6 hours 3. Change in blood concentrations of inflammatory markers over 6 hours All secondary outcomes are measured using blood testing at baseline (immediately before the meal) and 0.5, 1, 1.5, 2, 2.5, 3, 4, 5 and 6 hours after consuming the meal. | — |
Countries
England, United Kingdom
Outcome results
None listed