Association between sporadic dMMR status and the risk of non-colorectal malignancy in patients with known colorectal cancer Cancer
Conditions
Interventions
This study is a retrospective cohort describing the association between intestinal and not intestinal cancer among patients with different carcinogenetic backgrounds. This retrospective European multi
Sponsors
Cancer Research Foundation in Northern Sweden (Cancerforskningsfonden i Norrland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histologically confirmed CRC 2. Stage confirmed and transformed to the American Joint Committee on Cancer (AJCC) TNM classification 3. Available clinical and pathological data regarding the course of the disease and demographic data
Exclusion criteria
Exclusion criteria: 1. Patients younger than 18 years 2. Inconclusive immunohistochemical analysis (IHC) or missing data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The risk for non-colorectal malignancy before and after this diagnosis, compared to patients with different MMR tumors is measured using Incidence Rate Ratio (IRR) in both the univariable and multivariable analyses at one timepoint | — |
Secondary
| Measure | Time frame |
|---|---|
| Standardized incidence ratios (SIR) are calculated for each of the cancer forms reported (patients with pMMR and dMMR separately) and adjusted for sex, year (in one-year classes), and age (in five-year classes) at one timepoint | — |
Countries
Czech Republic, Finland, Sweden
Contacts
Public ContactKarin Strigård
Outcome results
None listed