Energy expenditure in obese and overweight individuals after a low energy followed by a high energy intervention

Glucose oxidation and resting energy expenditure in obese and overweight individuals after a low energy followed by a high energy intervention

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11596296

Enrollment

Registered

2017-05-18

Start date

2016-06-09

Completion date

Unknown

Last updated

2017-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obese and overweight individuals Nutritional, Metabolic, Endocrine Obese and overweight individuals

Interventions

Participants are provided with the information sheet at least 48 hours prior to commencing the study so that they have time to consider their participation. Pretest Following giving informed consent

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. BMI greater than 25kg/m2 2. Fat percentage higher than 22 at the body composition check 3. Aged from 18 to 60 years 4. Will not be diabetic or on a weight loss diet. At the beginning of the study, participants will complete a health-screening questionnaire and their anthropometric measurements will be taken. The health questionnaire will include questions regarding medical conditions and medication. If a participant presents a risk for disease or takes medication known to interfere with glucose metabolism, insulin signalling or energy metabolism they will be excluded from the study.

Exclusion criteria

Exclusion criteria: 1. Diabetic individuals 2. History of hypoglycemia 3. Individuals on a weight loss diet 4. High blood pressure (Hypertension) 5. Low blood pressure (Hypotension) 6. Individuals who does not fulfil the inclusion criteria

Design outcomes

Primary

Measure	Time frame
1. Glucose oxidation is measured using the 13C labelled glucose breath test at baseline, and then every 15 minutes for the next four hours 2. Metabolic rate is measured using indirect calorimetry at baseline (resting metabolic rate) at baseline and every 30 minutes for four hours. 3. Substrate oxidation is measured using indirect calorimetry (resting metabolic rate) at baseline and every 30 minutes for four hours.	—

Measure

Time frame

1. Glucose oxidation is measured using the 13C labelled glucose breath test at baseline, and then every 15 minutes for the next four hours 2. Metabolic rate is measured using indirect calorimetry at baseline (resting metabolic rate) at baseline and every 30 minutes for four hours. 3. Substrate oxidation is measured using indirect calorimetry (resting metabolic rate) at baseline and every 30 minutes for four hours.

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Secondary

Measure	Time frame
1. Plasma glucagon levels is measured from finger prick blood samples taken at baseline and every 15 minutes for the first 60 minutes after the drink and then every 30 minutes for four hours 2. Blood glucose blood levels is measured from finger prick blood samples taken at baseline and every 15 minutes for the first 60 minutes after the drink and then every 30 minutes for four hours 3. Insulin levels are measured from finger prick blood samples taken at baseline and every 15 minutes for the first 60 minutes after the drink and then every 30 minutes for four hours	—

Measure

Time frame

1. Plasma glucagon levels is measured from finger prick blood samples taken at baseline and every 15 minutes for the first 60 minutes after the drink and then every 30 minutes for four hours 2. Blood glucose blood levels is measured from finger prick blood samples taken at baseline and every 15 minutes for the first 60 minutes after the drink and then every 30 minutes for four hours 3. Insulin levels are measured from finger prick blood samples taken at baseline and every 15 minutes for the first 60 minutes after the drink and then every 30 minutes for four hours

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Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026