Urinary dysfunction Urological and Genital Diseases
Conditions
Interventions
Serum samples were collected from patients with various lower urinary tract symptoms (such as frequent urination, urgency, dysuria and incomplete voiding, etc), related diseases (including prostatitis
Sponsors
Wuxi No.2 People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Diagnostic criteria for interstitial cystitis: (satisfy both of the following conditions) 1.1. Pain in the bladder area or frequent urination and urgency 1.2. Intravesical instillation of normal saline to expand the bladder (pressure reaches 80cmH2O and maintained for 3 minutes), observing more than three quadrants with 10 or more bleeding points as positive. 2: Diagnostic criteria for prostatitis: 2.1. Those who meet the diagnostic criteria for chronic prostatitis according to Western medicine 2.2. Disease duration exceeds 3 months 2.3. No oral treatment with other medications within 2 weeks before entering the study cycle 3. Diagnostic criteria for bladder cancer: 3.1. Pathological diagnosis is the gold standard 4. Diagnostic criteria for prostate cancer: 4.1. Pathological diagnosis is the gold standard 5. Diagnostic criteria for overactive bladder (OAB): 1. Urgency score in the OABSS questionnaire is 2 points or above, and the total score is 3 points or above, excluding other pathological causes. Control Group Enrollment Criteria: Healthy examination personnel with age, gender, and education level matched to the refractory lower urinary tract dysfunction patients were selected from our hospital's health examination center using frequency matching. Among them, those with a HAMA scale score > 7 were included in the anxiety control group.
Exclusion criteria
Exclusion criteria: 1. Patients with urethral stenosis, urinary tract stones, urinary tract infection, urinary tract tumors, or neurogenic bladder 2. Women who are breastfeeding or pregnant 3. Patients with severe heart, liver, kidney, brain, and hematopoietic system diseases 4. Patients with central nervous system infection, head injury, epilepsy, multiple sclerosis, toxic metabolic diseases, Parkinson's disease, or intracranial tumors 5. Patients who have undergone pelvic surgery for pelvic organ prolapse or urinary incontinence 6. Patients with a family history of genetic diseases, a history of schizophrenia or personality changes, or a history of alcohol/drug dependence 7. Patients who have taken related cognitive-improving drugs 8. Patients with severe heart, liver, kidney, brain, and hematopoietic system diseases, or gynecological diseases such as vaginitis 9. Patients with contraindications to MRI scanning (such as implanted electronic or metal devices)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The central nervous system mechanisms underlying the occurrence and development of urinary dysfunction diseases were measured using multimodal neuroimaging scans performed the afternoon after admission. | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety measured using the Hamilton Anxiety Rating Scale (HAM-A) later in the morning of the second day after admission | — |
Countries
China
Contacts
Public ContactSiyi Fu
Outcome results
None listed