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Effects of blood flow restriction combined with moderate/high-intensity resistance training on hypertrophy adaptations

A randomized controlled trial to evaluate the effects of blood flow restriction combined with moderate or high-intensity resistance training versus moderate or high-intensity resistance training alone on muscular hypertrophy and strength adaptations in healthy resistance-trained adults

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN11518522
Enrollment
46
Registered
2026-01-16
Start date
2026-01-15
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The study addresses the domain of exercise physiology, focusing on optimizing resistance training methodologies for maximizing muscular hypertrophy and strength in healthy resistance-trained adults. Other

Interventions

This study will be conducted as a single-centre interventional randomized controlled trial comprising three sequential groups, to which participants will be randomly assigned prior to the start of the

Sponsors

Universitat Ramon Llull
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Sex: Participants must be men. 2. Age Range: Individuals between 18 and 35 years old. 3. Training Experience: Minimum of one year of consistent hypertrophy training (2–3 sessions per week per muscle group). 4. Confirmed Strength Level: Capable of performing a 1-repetition maximum (1RM) squat with a weight equivalent to 1.2 times their body mass. 5. Health Status: No history of cardiovascular or metabolic diseases, including venous thrombosis, coagulation disorders, heart disease, hypertension, varicose veins, or obesity. 6. Injury Status: No musculoskeletal injuries in the trained muscles within the last six months. 7. Substance Use: No use of anabolic steroids or other performance-enhancing drugs in the last year.

Exclusion criteria

Exclusion criteria: 1. Failure to Meet Inclusion Criteria: Individuals who do not meet any of the specified inclusion criteria (e.g., age range, male sex, minimum training experience, or baseline strength level). 1. Medical Contraindications: Presence of any cardiovascular, metabolic, or chronic disease (e.g., uncontrolled hypertension, coagulation disorders, deep vein thrombosis, or severe varicose veins) that contraindicates the safe use of Blood Flow Restriction (BFR). 3. Active Injury: Presence of any active or recent (last six months) musculoskeletal injury in the lower limbs or trunk that prevents the safe and correct execution of the training exercises. 4. Substance Use: Use of anabolic steroids or other performance-enhancing drugs within the last year. 5. Lack of Compliance Commitment: Inability or unwillingness to commit to the required two supervised training sessions per week for the full 15-week intervention period. 6. Lifestyle Interference: Inability or unwillingness to maintain stable daily routines regarding physical activity (outside the protocol), sleep patterns, and nutritional intake for the duration of the study, as assessed through the initial anamnesis. 7. Concurrent Participation: Simultaneous participation in any other exercise intervention study or any study involving performance-affecting supplementation.

Countries

Spain

Contacts

Public ContactJose Morales
josema@blanquerna.url.edu+34 646085312

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026