Patients undergoing coronary artery bypass grafting with cardiopulmonary bypass Surgery
Conditions
Interventions
Patients that required planned CABG surgery were randomly assigned for inclusion in one of two groups: (1) patients maintained by Conventional extracorporeal circulation system (n=20), (2) patients m
Sponsors
Amphia Ziekenhuis
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Elective isolated CABG surgery with CPB at Amphia hospital 2. Male or female =18 years 3. The graft material used could be the: left internal mammary artery (LIMA), Right internal mammary artery (RIMA), Saphenous vein or Radial artery
Exclusion criteria
Exclusion criteria: 1. The creatinine level >150µmol/L 2. Aspartate transaminase (ASAT) level >80 U/L 3. Ejection Fraction (EF) <30% 4. BSA <1.6, =2.5m² 5. Carotid artery stenosis 6. Hemoglobin level <7.5, =10 mmol/L 7. Pre-operative red blood cell transfusion, <14 days before CABG procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemolysis was measured using free Hb and LDH as parameters. Blood was obtained at baseline, at 5 and 30 min, 10 min after clamp removal, post ECC and post-surgery at the intensive care unit (ICU) | — |
Secondary
| Measure | Time frame |
|---|---|
| Cell death and neutrophil activation were measured using nucleosome and HNE-a1-ATc ELISA's. Blood was obtained at baseline, at 5 and 30 min, 10 min after clamp removal, post ECC and post-surgery at the intensive care unit (ICU) | — |
Countries
Netherlands
Outcome results
None listed