Diagnosis of liver injury in patients presenting with paracetamol overdose Injury, Occupational Diseases, Poisoning Poisoning by nonopioid analgesics, antipyretics and antirheumatics
Conditions
Interventions
Once consented:
1. Data will be collected on each patient including age, sex, gender, ethnicity, time of overdose, amount ingested, pattern of overdose, co-ingested medicines, blood re
Sponsors
Accord (United Kingdom)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Presentation at hospital within 5 days after suspected or confirmed paracetamol overdose (all patterns of overdose are eligible – including single and staggered overdoses whether accidental or deliberate) 2. Aged 16 years or older 3. Capacity to provide informed consent 4. Deemed suitable for study procedures by attending/treating clinician
Exclusion criteria
Exclusion criteria: 1. Deemed unfit by the Investigator or treating clinician to participate 2. Detained under the Mental Health (Care and Treatment) (Scotland) Act 2003
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. ALT measured as part of routine clinical care and recorded on the patient’s electronic medical record (daily blood results will be recorded up until day 30) 2. K18 in finger prick capillary blood measured using the Point of Care DILI Diagnostic (lateral flow assay combined with handheld Raman Spectrometer) at baseline, +2 hours then daily for up to 5 days whilst the participant is in hospital | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. ALT, INR and bilirubin measured as part of routine clinical care and recorded on the patient’s electronic medical record (daily blood results will be recorded up until day 30) 2. K18 from surplus blood serum measured by ELISA using the M65 Classic ELISA on days 1 and 2 if the participant is admitted and is in hospital on those days | — |
Countries
Scotland, United Kingdom
Contacts
Public ContactJoanne Mair
Outcome results
None listed