Compromised predicted adult height in girls with early or precocious puberty Nutritional, Metabolic, Endocrine
Conditions
Interventions
An initial phase IIa trial with 5 girls on the combined treatment for 1 year was performed. Girls with idiopathic precocious (<7.5yrs) or early (7.5-9yrs) puberty, all with a PAH lower than -2 or mor
Sponsors
Attikon University Hospital
Athens Medical Center
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Idiopathic precocious (breast development < 7.5 yrs) or early puberty (breast development 7.5-9 yrs) 2. Previously naïve to any hormonal therapy 3. PAH lower than -2 SDS or -1.5 SDS lower than their target height (mid parental height -6.5 cm)
Exclusion criteria
Exclusion criteria: 1. Organic precocious puberty 2. Syndromic, systemic or hereditary conditions that either impair growth or associate with PP 3. Bone diseases related to short stature (i.e. hypochondroplasia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Predicted adult height calculated according to the Bayley Pinneau tables with a bone age calculated according to the atlas of Greulich and Pyle, at 6-12-18-24 months. 2. Height velocity 3. Height for bone age 4. Bone age advancement 5. BMI Participants are followed until bone age reaches 14 or near adult height is achieved. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Potential hyperandrogenism (clinical or biochemical) 2. Ovarian cyst formation (pelvic ultrasound) 3. Bone mineral density (evaluated yearly by DXA) 4. Radiological evaluation of the lumbar spine (yearly) 5. Reports of peculiar behavior | — |
Countries
Greece
Outcome results
None listed