Cardiovascular: coronary artery disease Circulatory System Cardiovascular: coronary artery disease
Conditions
Interventions
Study participants firstly have been seen in a cardiology clinic where it will have been felt that coronary artery disease may be a possible cause of their chest pain, and hence they will undergo a CT
Sponsors
Royal Liverpool and Broadgreen University Hospitals NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Correlation of CT-FFR with stress CMR/ICA: 1. Aged 18 years or more 2. Undergoing CTCA for assessment of stable chest pain due to possible coronary artery disease who then go on to either stress CMR or ICA for further assessment of coronary artery disease reported on CTCA CT-FFR in coronary artery stented patients 1. Aged 18 or more 3. Coronary artery stent(s) undergoing CTCA for assessment of stable chest pain due to possible coronary artery disease who then go onto ICA for further assessment of coronary artery disease reported on CTCA
Exclusion criteria
Exclusion criteria: Correlation of CT-FFR with stress CMR/ICA: 1. Aged <18 years 2. Pregnancy 3. CKD with eGFR <30mL/min/1.73m2 4. Claustrophobia precluding CMR 5. Allergy to either iodinated (CT/ICA) or gadolinium based (CMR) contrast 6. Severe airways disease or high-degree heart block (Mobitz II/CHB) precluding regadenoson/adenosine CMR stress 7. Inability to peripherally cannulate patient for contrast administration 8. Learning difficulties/cognitive impairment precluding informed consent 9. Patient declines participation 10. Patients with stents will be excluded from this component of the study as they will be studied specifically in the second section of the study (below). We will know about the presence of a stent before the CTCA is performed (if referrer informs us or if not, we ask all patients if they have had stent(s)). CT-FFR in coronary artery stented patients 1. Aged <18 years 2. Pregnancy 3. CKD with eGFR <30mL/min/1.73m2 4. Allergy to iodinated (CT/ICA) contrast 5. Inability to peripherally cannulate patient for contrast administration 6. Learning difficulties/cognitive impairment precluding informed consent 7. Patient declines participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CT-FFR is measured using the CT-FFR analysis software from CTCA images taken at the patient's CTCA which is their first scan. This is then correlated with either (a) the presence or absence of ischaemia on their subsequent CMR which is assessed on visual analysis of stress perfusion imaging or (b) presence or absence of significant stenosis on their subsequent ICA which is assessed on visual analysis of the ICA images. | — |
Secondary
| Measure | Time frame |
|---|---|
| CT-FFR is measured using the CT-FFR analysis software from CTCA images taken at the patient's CTCA which is their first scan and correlated with presence or absence of significant stenosis using standard visual assessment on their CTCA images from the same scan 2. The proportion of coronary artery segments that are deemed on visual analysis of diagnostic, borderline-diagnostic and non-diagnostic quality using CT-FFR assessment and using visual assessment of CTCA images | — |
Countries
United Kingdom
Outcome results
None listed