N-3 polyunsaturated fatty acids and obesity

Caloric restriction and postprandial stress markers in healthy and obese people taking n-3 polyunsaturated fatty acids: BIOmarkers of Robustness of Metabolic Homeostasis for Nutrigenomics-derived Health CLAIMS Made on Food

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11445521

Enrollment

150

Registered

2015-02-20

Start date

2009-09-01

Completion date

Unknown

Last updated

2023-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy and obese subjects Nutritional, Metabolic, Endocrine Obesity

Interventions

1. Low calorie diet (1200–1500 kcal/day) or isocaloric diet combined marine n-3 PUFA (1.8 g/day) as oral supplements for 3 months 2. Low calorie diet (1200–1500 kcal/day) or isocaloric

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 25–65 years old 2. Body-mass index (BMI) 25–40 kg/m2 3. Not consuming fish oil or antioxidants 4. Willing to adhere to the study protocol 5. Able to provide written infomed consent

Exclusion criteria

Exclusion criteria: 1. Age 65 years old 2. BMI 40 kg/m2 3. Diabetes or other endocrine disorders 4. Chronic diseases (e.g., gastrointestinal problems, kidney diseases, liver diseases or cardiovascular problems) 5. Pregnant or planning to become pregnant during the study 6. Use of prescribed medications to control inflammation, blood lipids and glucose 7. Use of fish oil or other diet supplements

Design outcomes

Secondary

Measure	Time frame
1. Changes in serum glucose-dependent insulinotropic peptide during postprandial period and after diet and n-3 PUFA supplementation 2. Changes in osteocalcin serum concentrations after diet and n-3 PUFA supplementation 3. Lipidomic analysis in serum before and after intervention 4. Changes in serum adipokines and cytokines after diet and n-3 PUFA supplementation 5. Association of gene polymorphisms with response to diet and n-3 PUFA supplementation	—

Measure

Time frame

1. Changes in serum glucose-dependent insulinotropic peptide during postprandial period and after diet and n-3 PUFA supplementation 2. Changes in osteocalcin serum concentrations after diet and n-3 PUFA supplementation 3. Lipidomic analysis in serum before and after intervention 4. Changes in serum adipokines and cytokines after diet and n-3 PUFA supplementation 5. Association of gene polymorphisms with response to diet and n-3 PUFA supplementation

—

Primary

Measure	Time frame
1. Changes in metabolic and inflammatory biochemical markers after 3 moths of diet and n-3 PUFA supplementation 2. Changes in lipids and glucose metabolism markers during postprandial state in obese patients before and after intervention 3. Changes in expression of genes in peripheral blood mononuclear cells before and after intervention	—

Countries

Poland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026