Are certain forms of the P2Y2 gene associated with the risk of stroke in northern Han Chinese people?

G-Protein Coupled Purinergic Receptor P2Y2 (P2RY2) gene rs4944832 polymorphism increases the risk of ischemic stroke in the northern Han Chinese population

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN11439124

Enrollment

722

Registered

2018-10-24

Start date

2010-09-01

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke Circulatory System

Interventions

In this study, clinical data and peripheral blood specimens were collected from ischemic stroke patients and controls. The ischemic stroke participants were recruited from the First Affiliated Hospita

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria for the ischemic stroke group: 1. According to the TOAST classification, patients in the ischemic stroke group were diagnosed depending on clinical features and neuroimaging criteria that included the sudden onset of a global or focal neurological deficit, with corresponding brain infarction as seen on computed tomography (CT) imaging or magnetic resonance imaging (MRI) (Adams et al., 1993). Examinations of cerebral blood vessels, such as computed tomography angiography and magnetic resonance angiography, were performed when necessary. Inclusion criteria for the control group: 1. Unrelated healthy controls with no clinical or radiological evidence of stroke or cerebrovascular diseases. 2. Some healthy controls had vascular risk factors such as hypertension, diabetes, smoking, drinking, and hypercholesterolemia.

Exclusion criteria

Exclusion criteria: Exclusion criteria for the ischemic stroke group: 1. Cancer 2. Hemorrhagic stroke 3. Transient ischemic attack 4. Severe cardiac, hepatic, or renal diseases Exclusion criteria for control subjects: 1. Cancer 2. Autoimmune disease 3. Chronic inflammation 4. Renal insufficiency 5. Liver insufficiency 6. Hematopathy

Design outcomes

Primary

Measure	Time frame
The genotype frequencies of the three P2RY2 SNPs (rs4944831, rs1783596, and rs4944832) in ischemic stroke patients and controls.	—

Secondary

Measure	Time frame
1. Allele frequencies of the three P2RY2 SNPs (rs4944831, rs1783596, and rs4944832) in ischemic stroke patients and controls. 2. Inferred haplotypes of these three P2RY2 SNPs (rs4944831, rs1783596, and rs4944832).	—

Countries

China

Contacts

Public ContactLi-Ying Yuan

cmu_jane@sina.com13998250891

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 22, 2026