Tuberculosis and HIV Infections and Infestations Tuberculosis
Conditions
Interventions
Active Case-Finding (ACF) intervention: All symptomatic household members identified on brief door-to-door enquiry for chronic cough will be left information leaflets, sputum collection pots, with spu
Sponsors
London School of Hygiene & Tropical Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: For the ACF intervention: 1. Aged 18 years or older 2. Resident of an intervention cluster 3. Reported cough for 2 weeks or longer 4. Willing to provide sputum for TB testing following information provided in lieu of informed consent. For the post-intervention TB disease prevalence surveys: 1. Aged 18 years or older 2. Resident of an intervention or non-intervention cluster 3. Intending to remain within Blantyre City for at least the next 8 weeks 4. Willing to have radiological screening for TB (with abdominal screening for women of child bearing age) For the post-intervention Skin Test Survey: 1. Aged less than 3 years 2. Resident of an intervention or non-intervention cluster 3. Available for reading of results 48 to 72 hours after skin test placement
Exclusion criteria
Exclusion criteria: ACF participants: 1. Not currently on TB treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The prevalence of undiagnosed infectious tuberculosis among adult cluster residents (per 1000 population surveyed) post-intervention will be measured using digital chest x-rays read by an experienced radiographer assisted by computer assisted diagnostics. Participants reporting chronic cough or with abnormal chest x-ray will be asked to submit 2 sputum specimens for TB testing with Xpert (automated nucleic acid amplification test), microscopy and culture. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Post-intervention prevalence of latent TB infection in children aged<36 months. Children who are cluster residents will have 0.1 mls of skin test reagent placed by intradermal injection in the forearm, with return for reading at 48 to 72 hours. 2. Rate of treatment (per 1000 adult cluster residents per year) during the ACF intervention period, defined by entry into the District Health Office TB Treatment Register. 3. Post-intervention prevalence (per 1000 adult cluster residents) of having tested for TB (by self-report) by chest radiograph or sputum testing at facility-level, during the (actual/nominal) ACF intervention period. | — |
Countries
Malawi, United Kingdom
Contacts
Public ContactHelena Feasey
Outcome results
None listed