Topic: Dementias and Neurodegenerative Diseases Research Network
Conditions
Interventions
People with HD who enrol in the study will be asked to attend two research assessments (focussing on physical fitness, movement, thinking and walking abilities) over a three-month period at their loca
Sponsors
Cardiff University (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of manifest HD, confirmed by genetic testing 2. Male and female above the age of 18 3. Stable medication regime for four weeks prior to initiation of trial, and anticipated to be able to maintain a stable regime for the course of trial 4. Enrolled in European Huntington Disease Network (EHDN) Registry/ENROLL-HD study
Exclusion criteria
Exclusion criteria: 1. Any physical or psychiatric condition that would prohibit the participant from completing the intervention or the full battery of assessments 2. Inability to independently use the cycle ergometer 3. Unable to understand or communicate in spoken English (UK sites only) 4. Currently involved in any intervention trial or within four weeks of completing an intervention trial 5. Current, regular participation in a structured exercise programme five times per week or more
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility in terms of adherence, safety and process. Measures will be taken at baseline and 13 weeks. A follow-up telephone call will be made at 26 weeks to conduct the IPAQ and EQ-5D. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess benefit including physical fitness, cognitive ability and motor function. Measures will be taken at baseline and 13 weeks. A follow-up telephone call will be made at 26 weeks to conduct the IPAQ and EQ-5D. | — |
Countries
Germany, Netherlands, United Kingdom
Outcome results
None listed