Prevention of cardiometabolic diseases and reduction of environmental impact of food intake among healthy families Nutritional, Metabolic, Endocrine
Conditions
Interventions
The study is designed as a free-living, family-based, two-arm, parallel randomized controlled trial, comparing 1) a plant-rich and organic diet (intervention group) to 2) the habitual diet (control gr
Sponsors
Technical University of Denmark
Eligibility
Sex/Gender
All
Age
3 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Families and households with at least one participating parent and at least one participating child aged 3-17 years. 2. Families are eligible if they have a regular consumption of meat (meat or fish normally more than 4 times a week) and a majority of their fruits, vegetables, cereals, and bread purchases originates from conventional farming, i.e. at least half of the plant-based foods and products purchased in the household should be non-organic (self-reported)
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Diabetes type I and type II if medicated 3. Cancer treatment or recently had a major surgery 4. Users of weight loss medication (e.g. Wegovy) 5. Severe anaemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Plasma total cholesterol measured from fasting blood samples from all adults at baseline and follow-up 2. Pesticide metabolites excretion measured from first-morning urine samples on three days at baseline and follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| At baseline and follow-up: 1. Ratio of animal-sourced vs. plant-sourced proteins (AP) in the diet (adults and children using a digital seven-day dietary record) 2. Other cardiometabolic disease-related risk factors (LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose and insulin levels, blood pressure, anthropometric data and hsCRP) 3. Other dietary intake data: food groups (e.g. legumes, vegetables, fruits, meat, fish, dairy), macronutrients, micronutrients, and energy intake (using a digital seven-day dietary record) 4. Iron status (hemoglobin and ferritin) and vitamin B12 (cobalamin) (blood samples adults) 5. Sodium and potassium excretion (urine samples children and adults) 6. Parental attitudes, practices, self-efficacy and perceived social norms 7. Sustainability of the diet based on climate impact, land-use and biodiversity loss At follow-up: 8. Use and acceptability of the intervention components measured by a questionnaire among intervention families 9. Interviews post-intervention among selected intervention families | — |
Countries
Denmark
Contacts
Public ContactAnne Dahl Lassen
Outcome results
None listed