Postoperative gastric motility and stress response in patients undergoing elective laparoscopic cholecystectomy Surgery
Conditions
Interventions
Using a simple method of randomisation, patients were randomly assigned in a 1:1 ratio in the order of their admission into the hospital to receive either an in-house prepared oral honey solution (loc
Nutricia Advanced Medical Nutrition, Zoetermeer, The Netherlands). Both groups received 800 ml of their assigned solution orally on the evening before surgery and an additional 200 ml 2 hours prior to
Sponsors
Clinical Hospital Center Rijeka
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients (=18 years) 2. American Society of Anesthesiologists (ASA) physical status I–II 3. Scheduled for elective laparoscopic cholecystectomy
Exclusion criteria
Exclusion criteria: 1. History of neurosurgical procedures or head injuries 2. Prior hepatobiliary or gastrointestinal surgeries 3. Chronic renal insufficiency (creatinine clearance 3 14. Emergency surgery 15. Intraoperative identification of gallbladder inflammation 16. Conversion to open cholecystectomy 17. Advanced malignant disease discovered during the procedure 18. Intraoperative complications (e.g., significant bleeding, organ injury, or need for extended surgical resection)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Stress response, serum cortisol concentrations measured twice daily (08:00 and 16:00) on the day before surgery, on the day of surgery, and on the first postoperative day. Blood samples were collected into EDTA tubes and analyzed using validated commercial immunoassay kits. 2. Gastric motility was assessed indirectly through a paracetamol absorption test performed at baseline and 15, 30, 60, 120, and 180 minutes after ingestion using the ACET2 assay on a COBAS INTEGRA analyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Stress response measured using interleukin-6 (IL-6) levels at four timepoints: the day before surgery at 08:00, the morning of surgery at 08:00, six hours postoperatively, and on the first postoperative day at 16:00. The blood samples were collected into EDTA tubes and analyzed using validated commercial immunoassay kits. | — |
Countries
Croatia
Contacts
Public ContactJanja Tarcukovic
Outcome results
None listed