A study to evaluate the benefit of medical therapy versus angiography and stenting in patients with heart attacks - The BHF SENIOR RITA Trial

The British Heart Foundation older patients with non-ST SEgmeNt elevatIOn myocaRdial infarction Randomized Interventional TreAtment Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11343602

Enrollment

1680

Registered

2016-10-19

Start date

2016-10-24

Completion date

Unknown

Last updated

2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-ST segment elevation myocardial infarction Circulatory System Acute subendocardial myocardial infarction

Interventions

Following consent, patients will be randomized to one of two groups. Group 1: Participants undergo a coronary angiography (heart artery X-ray test) and, if appropriate, coronary revascularisation (tr

Eligibility

Sex/Gender

All

Age

75 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged =75 years 2. Type 1 NSTEMI during index hospitalisation

Exclusion criteria

Exclusion criteria: 1. Patients presenting with STEMI or unstable angina 2. Patients with cardiogenic shock 3. Patients with known life expectancy 4. Patients in whom neither the patient nor the consultee are able and willing to provide written informed consent 5. Previous inclusion in the BHF SENIOR-RITA trial 6. Inability to undergo invasive coronary angiography, such as no vascular access site, or absolute contraindication to coronary revascularisation

Design outcomes

Secondary

Measure	Time frame
1. All-cause, cardiovascular and non-cardiovascular death rates are measured using hospital records and ONS continuously until study end 2. Recurrent myocardial infarction rates are measured using patient records and HES data during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 3. Hospitalisation for heart failure rate is measured using patient records during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 4. Urgent coronary revascularisation rate is measured using patient records during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 5. Recurrent hospitalisation for myocardial infarction is measured using patient records during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 6. Stroke rate is measured using patient records and HES data during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 7. Bleeding (BARC =2) rate is measured using patient records and HES data during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 8. Procedural complication (including death, MI, major bleeding (BARC definition), = 25% increase in serum creatinine concentration from baseline, need for renal replacement therapy, stroke) rate is measured using hospital records during index hospitalisation (baseline) 9. Length of time spent at home is measured using the Time & Travel Questionnaire- telephone or clinic visit at 6 months 10. Frailty is measured using Fried and Rockwood frailty scores at baseline 6 months and 1 year and annually up to 5 years 11. Quality of Life is measured using EQ-5D-5L and quality adjusted life years (QALY) at baseline, 6 months and 1 year and annually up to 5 years 12. Costs to the NHS and personal social services are measured using a questionnaire at clinic or telephone at baseline, 6 months and 1 year and annually up to 5 years 13. Incremental cost per QALY gained at 1 year is me	—

Measure

Time frame

1. All-cause, cardiovascular and non-cardiovascular death rates are measured using hospital records and ONS continuously until study end 2. Recurrent myocardial infarction rates are measured using patient records and HES data during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 3. Hospitalisation for heart failure rate is measured using patient records during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 4. Urgent coronary revascularisation rate is measured using patient records during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 5. Recurrent hospitalisation for myocardial infarction is measured using patient records during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 6. Stroke rate is measured using patient records and HES data during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 7. Bleeding (BARC =2) rate is measured using patient records and HES data during index hospitalisation (Baseline), 6 months, 1 year and annually up to 10 years 8. Procedural complication (including death, MI, major bleeding (BARC definition), = 25% increase in serum creatinine concentration from baseline, need for renal replacement therapy, stroke) rate is measured using hospital records during index hospitalisation (baseline) 9. Length of time spent at home is measured using the Time & Travel Questionnaire- telephone or clinic visit at 6 months 10. Frailty is measured using Fried and Rockwood frailty scores at baseline 6 months and 1 year and annually up to 5 years 11. Quality of Life is measured using EQ-5D-5L and quality adjusted life years (QALY) at baseline, 6 months and 1 year and annually up to 5 years 12. Costs to the NHS and personal social services are measured using a questionnaire at clinic or telephone at baseline, 6 months and 1 year and annually up to 5 years 13. Incremental cost per QALY gained at 1 year is me

—

Primary

Measure	Time frame
Time to cardiovascular death or non-fatal MI within one year is determined by analysing the number of deaths one year after randomisation.	—

Countries

England, Scotland, United Kingdom, Wales

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 7, 2026