Moderate or severe periodontitis Oral Health
Conditions
Interventions
The study will use a split-mouth design, with each patient serving as their own control. Each quadrant (right upper jaw, left upper jaw, left lower jaw, right lower jaw) will be randomly allocated int
Sponsors
Beijing Chao-Yang Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 35-70 years 2. Minimum of 20 teeth (4 per quadrant) 3. It is clinically diagnosed as extensive stage III-IV periodontal disease: the heaviest site of interproximal attachment loss is =5 mm, radiologic bone loss extends to 1/3 of the root and above, PD = 6mm, vertical bone absorption =3 mm, cumulative bone resorption >30% 4. Good general health
Exclusion criteria
Exclusion criteria: 1. Received periodontal treatment within the previous 6 months 2. Received systemic antibiotic therapy within the previous 6 months 3. Suffered systemic diseases that could influence therapy outcome (e.g. diabetes mellitus, blood disease) 4. Pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Probing depth (PD) measured using periodontal probing at baseline, 3 months, and 6 months 2. Clinical attachment level (CAL) measured using periodontal probing at baseline, 3 months, and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Bleeding index (BI) measured using periodontal probing at baseline, 3 months, and 6 months 2. Plaque index (PLI) assessed by an examiner using a scale of 0 to 3 (where 0= No plaque, 1= Cannot see plaque but plaque can be detected with probe, 2= Moderate plaque can be seen, and 3= Lots of plaque can be seen) at baseline, 3 months, and 6 months | — |
Countries
China
Outcome results
None listed