Prevention and reduction of gingivitis and halitosis in healthy adult Oral Health
Conditions
Interventions
This study is a randomized, cross-over pilot experiment on 10 subjects. Each subject tested one chewing gum and, after a washout period of one week, another chewing gum containing a different strain,
Sponsors
University of Milan
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult subjects aged 18 to 64 years 2. Presence of at least 24 natural teeth (excluding third molars) 3. Gingival index and plaque index scores = 2 4. A stimulated salivary flow rate between 1.5 and 2.0 mL/min
Exclusion criteria
Exclusion criteria: 1. The presence of systemic diseases 2. Pregnancy or lactation 3. History of drug abuse 4. Smoking habits 5. Use of fixed orthodontic appliances 6. Allergies to any ingredients in the chewing gums used
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Viable bacterial cells in saliva measured using dilution plating onto selective media to count colony-forming units per 1 mL of culture (CFUs/mL) before chewing gum use (T0), and at 1, 5, 10, and 20 min, as well as 1 and 2 h after the procedure began (T1–T6). For H. coagulans SNZ1969, part of the samples underwent viable count after pasteurization (incubation in a water bath at 90 °C for 10 min) to quantify bacterial spores. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects reported by participants measured by an investigator who conducted brief telephone interviews with the participants on the evening of the intervention day and one week later to record any side effects associated with the chewing gum administered | — |
Countries
Italy
Contacts
Public ContactClaudia Salerno
Outcome results
None listed