Using the oxygen content of venous blood to guide the fluid balance of haemodialysis patients

Using central venous saturations >65% as an objective target for goal directed fluid management in haemodialysis patients using a tunneled venous catheter: a proof of concept trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11322777

Enrollment

Registered

2015-01-30

Start date

2015-05-01

Completion date

Unknown

Last updated

2018-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with end stage renal failure receiving maintenance haemodialysis though a tunneled internal jugular dialysis catheter Urological and Genital Diseases

Interventions

The intervention is an incremental increase in target weight by 0.5 kg per dialysis session.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged > 18 years old 2. Diagnosed with ESRD on maintenance haemodialysis via a central venous catheter 3. Haemoglobin >10mg/dL 4. Patient is able and willing to give informed consent

Exclusion criteria

Exclusion criteria: 1. There is planned and imminent movement of the patient to a satellite haemodialysis unit 2. Individuals requiring supplementary oxygen routinely 3. The presence of a functioning fistula 4. There is planned and imminent surgery for transplantation and/or fistula formation 5. Patient survival predicted to be <3months

Design outcomes

Primary

Measure	Time frame
Post dialysis ScvO2 measured by blood gas analysis	—

Secondary

Measure	Time frame
1. Cardiac output using the Cheetah NICOM both pre and post dialysis as described 2. Adverse events that may occur as a result of the study intervention 3. QOL questionnaire	—

Countries

United Kingdom

Contacts

Public ContactAdam Kirk

adam.kirk@porthosp.nhs.uk+44 (0)7966 015047

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026