Faecal volatiles in children with inflammatory bowel disease

Evaluation of faecal volatile organic compounds in the diagnosis of paediatric inflammatory bowel disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN11314352

Enrollment

286

Registered

2017-07-31

Start date

2017-06-27

Completion date

Unknown

Last updated

2023-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory bowel disease and common gastrointestinal disorders in children referred for specialist paediatric gastroenterology review Digestive System Inflammatory bowel disease

Interventions

Potential participants will be identified by their clinical team by reviewing referrals to out-patient clinics, children attending for ward review or referred directly for investigations such as endos

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Children (age <18 years) capable of giving informed consent, or if age < 16 years or not capable of giving consent, with an acceptable individual capable of giving consent on the child’s behalf 2. Children of either gender attending a paediatric gastroenterology referral clinic in whom IBD is suspected following initial clinical assessment ? 3. Further evaluation planned to diagnose the cause of the child's illness 4. Willing for demographic and clinical information to be used for the purposes of the study 5. Willing for part of the stool sample provided for routine clinical assessment to be used for the measurement of VOCs ?

Exclusion criteria

Exclusion criteria: 1. Treatment already received for IBD (e.g. polymeric formula feeds in children awaiting investigation) 2. Established diagnosis of a significant gut disorder (e.g. short bowel syndrome) 3. Failure to obtain informed consent from the young person or parent/guardian

Design outcomes

Primary

Measure	Time frame
Faecal VOCs at initial presentation to paediatric gastroenterology measured by headspace SPME-Combipal GCMS and the GC-sensor Odoreader© at initial presentation.	—

Secondary

Measure	Time frame
1. Faecal VOCs at initial presentation in children with IBD according to IBD diagnosis, distribution and disease severity 2. Faecal VOCs at 3 months after the initial presentation in children with inflammatory bowel disease according to disease activity 3. Likely source of the faecal VOCs identified by GCMS at initial presentation determined by existing KEGG databases (http://www.genome.jp/kegg/kegg2.html)	—

Measure

Time frame

1. Faecal VOCs at initial presentation in children with IBD according to IBD diagnosis, distribution and disease severity 2. Faecal VOCs at 3 months after the initial presentation in children with inflammatory bowel disease according to disease activity 3. Likely source of the faecal VOCs identified by GCMS at initial presentation determined by existing KEGG databases (http://www.genome.jp/kegg/kegg2.html)

—

Countries

England, United Kingdom

Contacts

Public ContactStephen Allen

stephen.allen@lstmed.ac.uk+44 151 705 3752

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026