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Aerosol clearance in patients with and without long COVID

A feasibility study to assess alveolar epithelial permeability in smoking and non-smoking control groups and patients suffering ongoing symptoms more than 4 weeks since COVID-19 infection (long COVID) using pulmonary clearance of [99mTc]DTPA aerosol measured by lung scintigraphy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN11309292
Enrollment
100
Registered
2022-06-01
Start date
2022-07-08
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Long COVID Infections and Infestations

Interventions

Current intervention as of 11/07/2022: Potential participants will be identified from the referral information on the radiology information system (RIS). No other method will be used to identify poten

Sponsors

NHS Tayside
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients referred to the Department of Nuclear Medicine, Ninewells Hospital, Dundee for a lung V/Q scan as part of their standard of care 2. Participants must be 18 years old or above

Exclusion criteria

Exclusion criteria: 1. Below 18 years of age 2. Pregnant 3. Lack of capacity to provide informed consent 4. Involved in current research or have recently been involved in any research prior to recruitment

Design outcomes

Primary

MeasureTime frame
The clearance half time of [99mTc]DTPA aerosol from the lungs measured by lung scintigraphy on the day of recruitment in non-smoking patients with a clinical history of long COVID

Secondary

MeasureTime frame
The clearance half time of [99mTc]DTPA aerosol from the lungs measured by lung scintigraphy on the day of recruitment in: 1. Smoking patients with a clinical history of long COVID 2. Non-smoking patients with no history of interstitial lung or airways disease 3. Smoking patients with no history of interstitial lung or airways disease

Countries

Scotland, United Kingdom

Contacts

Public ContactThomas Biggans
thomas.biggans@nhs.scot+44 (0)1382 633888

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026