Topic: Renal disorders
Conditions
Interventions
The study will compare six month of cycling exercise during dialysis (intervention group) against normal dialysis care (no intervention). The intervention group will use specially adapted and calibrat
Sponsors
University of Leicester (UK)
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Be a prevalent haemodialysis patient (on haemodialysis for more than 3 months) 2. Age 18 years or older 3. Able and willing to give informed consent
Exclusion criteria
Exclusion criteria: 1. Unable to participate in current exercise program due to perceived physical or psychological barriers 2. Unable to undergo MRI scanning (metal implants / prostheses, claustrophobia etc.) 3. Unfit to undertake exercise according to the American College of Sports Medicine guidelines 4. Contraindications to exercise testing (35) that include: 4.1. Recent significant change in resting ECG that suggests significant ischaemia, recent myocardial infarction (2 weeks) or other acute cardiac event; 4.2. Unstable angina; 4.3. Uncontrolled cardiac dysrhythmias causing symptoms or haemodynamic compromise; 4.4. Symptomatic severe aortic stenosis 4.5. Uncontrolled symptomatic heart failure 4.6. Acute pulmonary embolus or pulmonary infarction 4.7. Acute myocarditis or pericarditis 4.8. Suspected or known dissecting aneurysm 4.9. Acute systemic infection, accompanied by fever, body aches or swollen lymph glands 5. Age <18 years 6. Unable or unwilling to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in left ventricular mass; Timepoint(s): Measured at baseline and after 6-months of exercise intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Measurements of cardiac structure and function measured using MRI and echocardiography (e.g. left ventricular ejection fraction, blood oxygen delivery) 2. Cardiac rhythm measured using 48 hour ambulatory monitoring 3. Non-invasive cardiac measurements (e.g.blood pressure) 4. Measurements of height, weight, waist circumference and body composition analysis 5. Physical functioning measures including walking and standing tests 6. Objective assessment of habitual physical activity using accelerometry 7. Quality of life and perceived function scores using a variety of validated questionnaires 8. Blood markers of myocardial dysfunction and risk 9. Blood markers of the malnutrition and inflammation | — |
Countries
England, United Kingdom
Contacts
Public ContactJames Burton
Outcome results
None listed