Obesity Nutritional, Metabolic, Endocrine Obesity
Conditions
Interventions
Current interventions as of 14/05/2019:
Women will be recruited from the Greater Dublin area. They will self identify to the research team in response to flyers, recruitment stalls, social media alert
or the control group who will consume a placebo capsule daily for 12 weeks. The study statistician, who will not be involved in data collection, will produce computer-generated sets of random allocati
Sponsors
University College Dublin
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Current participant inclusion criteria as of 14/05/2019: 1. Non-pregnant women aged between 18 to 65 years capable of giving informed consent 2. BMI = 30Kg/m^2 3. Waist circumference > 80cm OR waist:hip ratio = 0.85 4. Raised fasting triglyceride levels Previous participant inclusion criteria: 1. Non-pregnant women aged between 18 to 45 years capable of giving informed consent 2. BMI = 30Kg/m^2 3. Waist circumference > 80cm OR waist:hip ratio = 0.85 4. Raised fasting triglyceride levels
Exclusion criteria
Exclusion criteria: Current participant exclusion criteria as of 14/05/2019: 1. Pregnant or planning to become pregnant in the following 6 months 2. Age 65 years 3. Inadequate level of English to provide informed consent or communicate with the researchers 4. Having a condition or taking a medication, dietary supplement or food product that the investigator believes would interfere with the objectives of the study 5. Actively involved in a weight-loss programme Previous participant exclusion criteria: 1. Pregnant or planning to become pregnant in the following 6 months 2. Age 45 years 3. Inadequate level of English to provide informed consent or communicate with the researchers 4. Having a condition or taking a medication, dietary supplement or food product that the investigator believes would interfere with the objectives of the study 5. Actively involved in a weight-loss programme
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of C-reactive protein, measured by laboratory analysis at baseline and at 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Collected at baseline and at 12 weeks: 1. Body weight and body fat change, determined by changes in BMI, waist circumference, waist:hip ratio. 2. Inflammation, investigated by measuring changes in inflammatory markers including TNF-alpha 3. Insulin resistance, determined using HOMA index and HbA1c 4. Lipids, assessed by analysis of circulating lipids | — |
Countries
Ireland
Outcome results
None listed