Remote rehabilitation after intensive care

Conditions

Any condition requiring admission to intensive care and 48 hours of invasive mechanical ventilation Other

Cara G. Ghiglieri, Bronwen Connolly, Darren Murphy, Daniel F. McAuley, Brenda M. O’Neill et al. (62 authors)

Journal of Intensive Care2026-07-26

10.1186/s40560-026-00908-0

Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors

B ONeill, Judy M. Bradley, B; id_orcid 0000-0002-5676-5497 Connolly, Julie Bruce, Mariam Ratna et al. (80 authors)

JAMA2026-05-18

10.1001/jama.2026.7401

Development of a patient centred, structured, individually tailored, multi-component intervention to promote rehabilitation and recovery after critical illness: content, theory, and construction.

O'Neill B, McAuley D, Clarke R, Duncan S, Firshman P, Terblanche E, Bruce J, Costley J, Connolly B, Martina Bradley J.

2025-10-06

10.3310/nihropenres.14023.2

Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge (iRehab): a protocol for a randomised controlled assessor-blind clinical and cost-effectiveness trial

Brenda O’Neill, Judy Bradley, Bronwen Connolly, Julie Bruce, Martin Underwood et al. (23 authors)

NIHR Open Research2025-08-22

10.3310/nihropenres.13910.2

Development of a patient centred, structured, individually tailored, multi-component intervention to promote rehabilitation and recovery after critical illness: content, theory, and construction.

Brenda O’Neill, Daniel F. McAuley, Rachel Clarke, Sallyanne Duncan, Penelope Firshman et al. (10 authors)

NIHR Open Research2025-08-04

10.3310/nihropenres.14023.1

Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge (iRehab): a protocol for a randomised controlled assessor-blind clinical and cost-effectiveness trial

Brenda O’Neill, Judy Bradley, Bronwen Connolly, Julie Bruce, Martin Underwood et al. (23 authors)

NIHR Open Research2025-04-102 citations

10.3310/nihropenres.13910.1

Interventions

Six-week remote multi-component, individualised, rehabilitation intervention incorporating: weekly symptom management

targeted exercise

psychological support

and peer support and information compared to standard care Half of the participants will be randomised to receive standard NHS care and half will receive the 6-week iRehab programme. The randomisatio

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults within 12 weeks of hospital discharge after treatment of a critical illness requiring ICU care and mechanical ventilation for =48 hours

Exclusion criteria

Exclusion criteria: 1. Declined consent or unable to provide consent 2. Previous randomisation into the present trial 3. Participating in another rehabilitation or self-management support trial 4. Contra-indication to exercise 5. Severe mental health problems that preclude participation in a group intervention 6. Discharged to a rehabilitation unit, or care home with/without nursing care 7. Prisoners

Design outcomes

Primary

Measure	Time frame
Health-related quality of life (HRQoL) measured using EQ-5D-5L at 8 weeks	—

Secondary

Measure	Time frame
1. Physical function measured using 30-sec Sit-To-Stand at 8 weeks and 6 months 2. Illness perceptions measured using Brief Illness Perceptions Questionnaire at 8 weeks and 6 months 3. Fatigue measured using Functional Assessment of Chronic Illness therapy at 8 weeks and 6 months 4. Anxiety and depression measured using the Hospital Anxiety and Depression Scale (HADS) at 8 weeks and 6 months 5. Health and social care use measured using the healthcare and social care utilisation questionnaire at 8 weeks and 6 months 6. Safety measured using data on serious adverse events collected at 8 weeks and 6 months Added 10/10/2023: 7. Intervention acceptability measured using a Theoretical Framework Acceptability Questionnaire (TFAQ) at 8 weeks	—

Measure

Time frame

1. Physical function measured using 30-sec Sit-To-Stand at 8 weeks and 6 months 2. Illness perceptions measured using Brief Illness Perceptions Questionnaire at 8 weeks and 6 months 3. Fatigue measured using Functional Assessment of Chronic Illness therapy at 8 weeks and 6 months 4. Anxiety and depression measured using the Hospital Anxiety and Depression Scale (HADS) at 8 weeks and 6 months 5. Health and social care use measured using the healthcare and social care utilisation questionnaire at 8 weeks and 6 months 6. Safety measured using data on serious adverse events collected at 8 weeks and 6 months Added 10/10/2023: 7. Intervention acceptability measured using a Theoretical Framework Acceptability Questionnaire (TFAQ) at 8 weeks

—

Countries

England, Northern Ireland, Scotland, United Kingdom, Wales

Outcome results

None listed