Peri-operative analgesia Surgery Pain relief
Conditions
Interventions
Group A: Intravenous injection equivalent to one gram paracetamol given by the researchers immediately prior to induction of anaesthesia in theatre.
Group B: One gram oral paracetamol prescribed on th
Sponsors
North Bristol NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Assessment of fitness as indicated by the American Society of Anesthesiologists (ASA) grades I and II 2. Age group 16 to 75 years 3. All patients listed for elective surgery by Mr P Robinson on a Thursday for Ear, Nose & Throat surgery
Exclusion criteria
Exclusion criteria: 1. Patients refusing to participate in study 2. Patient unable to take an oral preparation 3. Cases shorter than one hour 4. Patients already taking a paracetamol containing drug combination, or have taken in the last 12 hours 5. Patients with a history of paracetamol allergy, hypersensitivity or previous reaction/serious adverse reaction 6. Children under the age of 16 7. Patients unable to understand or give consent to participation in the study; incapable adults, psychiatric/medical disorder able to modify patient compliance 8. Pregnant or breastfeeding 9. History of complete non-responsiveness to acetaminophen 10. Pancreatic disease in the previous 12 months 11. Impaired liver/kidney function 12. Patients that might pose an infection risk to staff due to blood products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Therapeutic plasma level of paracetamol (when the plasma level is 10 - 20 mg/l [the test will be at 30 minutes post induction of anaesthesia]) | — |
Secondary
| Measure | Time frame |
|---|---|
| Non-therapeutic plasma level of paracetamol | — |
Countries
United Kingdom
Outcome results
None listed