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Blood flow restriction exercise therapy for people with obesity

Effects of blood flow restriction training on metabolomics and proteomics in patients with obesity

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN11246966
Enrollment
36
Registered
2025-05-08
Start date
2025-05-15
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise and metabolic improvement in obese adolescents Nutritional, Metabolic, Endocrine

Interventions

Participants were randomly assigned to two experimental groups (M and B) and one control group (C) by drawing lots. The intervention period lasted for a total of 12 weeks, with three sessions per week

Sponsors

Ocean University of China
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 18-25 years 2. Body fat percentage greater than 30% 3. No long-term medication, smoking, or excessive drinking habits 4. No exercise-related contraindications, such as cardiovascular and cerebrovascular diseases, respiratory system diseases, etc

Exclusion criteria

Exclusion criteria: Suffering from any illness that is not suitable for participating in sports

Design outcomes

Primary

MeasureTime frame
Measured at baseline and after the intervention: 1. Plasma non-targeted metabolomics data is measured using liquid chromatography-mass spectrometry (LC-MS) 2. Plasma proteomics data is measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS) 3. Plasma-targeted metabolomics data is measured using liquid chromatography-mass spectrometry (LC-MS)

Secondary

MeasureTime frame
Measured 3 weeks before the start of the intervention and during the 12-week intervention period: 1. Daily dietary intake measured using a questionnaire every weekend 2. Physical activity measured using a questionnaire every weekend 3. Aerobic capacity is measured using cardiopulmonary exercise testing (CPET), typically with a cycle ergometer, to determine VO2 max (maximal oxygen uptake) 4. Body composition is measured using bioelectrical impedance analysis (BIA) 5. Abdominal subcutaneous fat area is measured using computed tomography (CT) scans 6. Visceral fat area is measured using computed tomography (CT) scans

Countries

China

Contacts

Public ContactShiming Li
haiyanglishiming@163.com+86 (0)15731114483

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 29, 2026