FINE-ST: Frailty and inequality in stroke

Frailty, Inequality and Co-morbidity: a cohort study in TIA and Stroke

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN11241011

Enrollment

200

Registered

2022-03-21

Start date

2020-09-17

Completion date

Unknown

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To initiate a stroke cohort to inform the relationship between frailty, multi-morbidity, socioeconomic status and clinical outcome in TIA and stroke. Nervous System Diseases Transient cerebral ischaemic attacks and related syndromes

Interventions

The study simply collects information through administration of a questionnaire at two time points (baseline and 90 days later) in two groups (within 6 weeks of the TIA/stroke

and >6 weeks of the TIA/stroke). The questionnaire at baseline is administered either face-to-face whilst in hospital, or sent via the post if the participant is at home. The questions asked 90 days l

Eligibility

Sex/Gender

All

Age

40 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. TIA, ischaemic or haemorrhagic stroke in the last: 6 weeks (subacute group), or 6 weeks to 3 years (chronic group) 2. Age >40 years 3. Written consent from participant or proxy

Exclusion criteria

Exclusion criteria: 1. Probable stroke mimic (e.g. migraine, functional neurology, brain tumour) 2. Life expectancy <3 months 3. Not expected to complete follow up at day 90 (e.g. homeless, out-of-area) 4. Level of consciousness prohibits engagement in baseline measures

Design outcomes

Primary

Measure	Time frame
1. Frailty will be measured using the CFS, PRISMA 7 and FI-GCA at baseline and day 90. 2. Functional outcome will be measured using the MRS at baseline and day 90.	—

Secondary

Measure	Time frame
1. Frailty will be measured using the CFS, PRISMA 7 and FI-GCA at baseline and day 90. 2. Disability will be measured using the Barthel Index (BI) at baseline and day 90. 3. Dysphagia will be measured using the Dysphagia Severity Rating Scale (DSRS) at baseline and day 90 4. Cognition will be measured using the Montreal Cognitive Assessment (MoCA) and Telephone Mini Mental State Examination (t-MMSE) at baseline and day 90 5. Mood will be measured using the Geriatric Depression Scale (GDS) and Zung Depression Scale (ZDS) at baseline and day 90. 6. Inequality will be measured using the English Indices of Deprivation scale at baseline and day 90. 7. Fatigue will be measured using the Fatigue Assessment Scale (FAS) at baseline and day 90. 8. Co-morbidity will be measured using the Charleston Co-morbidity Index (CCI) at baseline.	—

Measure

Time frame

1. Frailty will be measured using the CFS, PRISMA 7 and FI-GCA at baseline and day 90. 2. Disability will be measured using the Barthel Index (BI) at baseline and day 90. 3. Dysphagia will be measured using the Dysphagia Severity Rating Scale (DSRS) at baseline and day 90 4. Cognition will be measured using the Montreal Cognitive Assessment (MoCA) and Telephone Mini Mental State Examination (t-MMSE) at baseline and day 90 5. Mood will be measured using the Geriatric Depression Scale (GDS) and Zung Depression Scale (ZDS) at baseline and day 90. 6. Inequality will be measured using the English Indices of Deprivation scale at baseline and day 90. 7. Fatigue will be measured using the Fatigue Assessment Scale (FAS) at baseline and day 90. 8. Co-morbidity will be measured using the Charleston Co-morbidity Index (CCI) at baseline.

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Countries

England, United Kingdom

Contacts

Public ContactDiane Havard

diane.havard@nottingham.ac.uk+44 (0)115 8231775

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 17, 2026