Rheumatoid arthritis Musculoskeletal Diseases
Conditions
Interventions
Immunological phenotyping and qualitative interview
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of rheumatoid arthritis according to the 1987 American College of Rheumatology (ACR) (Appendix B) or 2010 ACR/European Alliance of Associations for Rheumatology (EULAR) classification criteria (Appendix C) applied at any time since diagnosis. 2. Previous or current use of a disease-modifying anti-rheumatic drug (conventional synthetic, targeted synthetic, or biological)
Exclusion criteria
Exclusion criteria: 1. Unable to read or communicate in English 2. Inability to provide informed consent 3. Age less than 18 years 4. Current pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At a single time point: 1. Characterisation of CD4+ regulatory T cell and B cell phenotype in patients in sustained drug-free remission using conventional and spectral flow cytometry 2. Quantification of CD4+ regulatory T cell function in sustained drug-free remission through the use of in vitro autologous T cell suppression assays | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify, characterise and understand patients’ experience of sustained drug-free remission by interview at a single time point | — |
Countries
England, United Kingdom
Contacts
Public ContactKenneth Baker
Outcome results
None listed