Obstetric haemorrhage Pregnancy and Childbirth
Conditions
Interventions
Preoperative intravenous tranexamic acid 1g(10mls) vs Preoperative intravenous water for injection (10mls) as placebo.
Randomization into groups is by simple balloting, drawing numbers
Sponsors
Irrua Specialist Teaching Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. All pregnant women scheduled for a primary Caesarean section 2. Singleton pregnancy
Exclusion criteria
Exclusion criteria: 1. Multiple gestation 2. Any other additional risk of bleeding apart from the Caesarean section such as previous caesarean section, antepartum haemorrhage, polyhydramnios and bleeding disorders. 3. Liver or Renal pathologies 4. Patients who chose not to participate in the study. 5. Allergy to Tranexamic acid 6. Women unfit to give an informed consent e.g. the eclamptic, unconscious or those with mental impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss at Caesarean section and within 24 hours after surgery using galvametric and volumetric approach of estimation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The difference in 1hr preoperative packed cell volume and 48hrs postoperative packed cell volume. 2. Additional oxytocic requirement, blood transfusion, caesarean hysterectomy or maternal death as a result of primary Post Partum Haemorrhage. 3. APGAR scores in first and fifth minutes and Neonatal Intensive care unit admissions/outcome. 4. Maternal satisfaction prior to discharge measured using a scale of 0-10; Where 0- extreme dissatisfaction and 10-ultimate satisfaction | — |
Countries
Nigeria
Contacts
Public ContactOlorungbogo Olugbenga
Outcome results
None listed