Critically ill patients following cardiac surgery Circulatory System Critically ill patients following cardiac surgery
Conditions
Interventions
Participants undergo blood sampling for 24 hours via their in situ lines from 8am in the morning. Cortisol sampling of 0.7ml is taken every 10 minutes. Blood sampling for ACTH occurs at hourly interva
Sponsors
University of Bristol
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Consultee of opinion that patient would consent 2. Male 3. Ages 18 – 80 undergoing cardiac surgery 4. At least 2 of the following on day 2 or later post cardiac surgery: 4.1. Ventilation 4.2. Concurrent use of inotropes and/or vasopressors 4.3. Haemo(dia)filtration
Exclusion criteria
Exclusion criteria: 1. Consultee of opinion that patient would not consent 2. Current or recent (within 3 months) use of glucocorticoids 3. Disorders of the HPA axis 4. Thyroid disease 5. Etomidate use at any stage of the surgical pathway
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortisol is measured using blood samples taken every ten minutes which will generate a profile over 24 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Adreno-corticotrophic hormone is measured using blood samples taken at hourly intervals 2. Cortisol Binding Globulin (CBG) is measured using blood samples taken at baseline and 24 hours 3. Inflammatory mediators are measured using blood samples taken at every four hours | — |
Countries
United Kingdom
Contacts
Public ContactJonathan Evans
Outcome results
None listed