Surgery on the ascending aorta/proximal aortic arch Surgery
Conditions
Interventions
The patients will be randomly allocated into two groups (15 in each group with 10% drop out) using computerised simple block randomisation.
Normal practice: Control Group 1
Sponsors
University Hospital of South Manchester NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All patients undergoing elective proximal aortic arch surgery with deep hypothermia circulatory arrest 2. Patients who have given written informed consent to take part in this study
Exclusion criteria
Exclusion criteria: 1. Patients who are not undergoing deep hypothermia circulatory arrest 2. Patients undergoing emergency operations 3. Refusal to take part in the study 4. Patients who have a history of epistaxis (nasal bleeding) requiring hospital intervention 5. Patients who have a history of nasal obstruction 6. Patients who have a history of deviated nasal septum 7. Patients who have a history of coagulopathy 8. Patients who have a history of liver dysfunction 9. Patients who have a history of renal dysfunction and also less than GFR 30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess if transnasal brain cooling has any effect on reducing postoperative neurological dysfunction | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Assess the effect of transnasal brain cooling on: 1.1. Early mobilisation 1.2. Length of hospital stay 1.3. Requirement of sedative medications for confusion and delirium 2. Assess the effect on brain and core temperature trends when trans-nasal brain cooling is used prior to and during deep hypothermia | — |
Countries
United Kingdom
Outcome results
None listed