A feasibility study of treatments for Dupuytren's contracture (HAND-1)

Conditions

Topic: Musculoskeletal disorders

Davis TRC, Tan W, Harrison EF, Hollingworth W, Karantana A, Mills N, Hepburn T, Sprange K, Duley L, Blazeby JM, Bainbridge CG, Murali SR, Montgomery AA, HAND-1 Study group.

2020-01-3011 citations

10.1186/s40814-019-0546-y

A feasibility study investigating the acceptability and design of a multicentre randomised controlled trial of needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren's contractures of the fingers (HAND-1): study protocol for a randomised controlled trial.

Harrison E, Tan W, Mills N, Karantana A, Sprange K, Duley L, Elliott D, Blazeby J, Hollingworth W, Montgomery AA, Davis T.

2017-08-2512 citations

10.1186/s13063-017-2127-9

Interventions

1. Needle fasciotomy - This procedure takes place in an outpatient clinic room setting. The contracture is divided with a needle which pierces the skin (no skin incision) 2. Limited fa

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged over 18 years. 2. One or more fingers with a Dupuytren’s contracture of >30° in the metacarpophalangeal (MCP) and/or proximal interphalangeal joints (PIP). 3. Well defined cord(s) causing contracture. 4. No previous surgery for Dupuytren’s contracture on the same hand. 5. Willing to undergo either study procedure. 6. Able to complete follow up assessments.; Target Gender: Male & Female ; Lower Age Limit 18 years

Exclusion criteria

Exclusion criteria: 1. Dupuytren's contracture of the distal interphalangeal joints (DIP) only 2. Planned dermofasciectomy or very limited fasciectomy (excision of =1cm cord segment) 3. Previously recruited into this study for treatment of either hand 4. Life expectancy less than 3 years

Design outcomes

Primary

Measure	Time frame
Multi outcomes; Timepoint(s): baseline, Day of surgery, 2 weeks post-surgery, 6 weeks post-surgery and 6 months post-surgery	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed