Impaired glucose tolerance Nutritional, Metabolic, Endocrine
Conditions
Interventions
An impaired-OGTT is defined according to the guidelines provided by the American Diabetes Association, namely the following changes in blood glucose levels in response to ingestion of 75g glucose diss
Sponsors
University of Fribourg - Faculty of Science
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Healthy 2. Non-smokers 3. BMI between 18 and 39.9 kg/m2 4. 20-45 years old
Exclusion criteria
Exclusion criteria: 1. Participants diagnosed as diabetics based on the following criteria: fasting glucose levels equal to or exceeds 126 mg/dL (7.0 mmol/L), and b) 2-h glucose equal to or exceeds 200 mg/dL (11.1 mmol/L) 2. Any medical condition which could interfere with the measured variables, e.g. cardiovascular-, gastrointestinal-, neurological-, and overt metabolic disorders 3. Subjects under current medication (either for acute or chronic illnesses) 4. Competition athletes, smokers, or overtly sedentary, or have eating disorders 5. Subjects who fear or have adverse reactions to cannulation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Haemodynamics: Measurements will be performed continuously starting with a 30 min baseline and continued after the OGTT for another 120 min using a Task Force Monitor (CNSystems). Haemodynamic parameters are: Blood pressure (systolic and diastolic), heart rate, stroke volume 2. Blood parameters: Measurements will be performed at the end of the baseline (30 min) and after the OGTT consecutively every 30 min until the end of the OGTT, i.e. 120 min post-drink. Blood parameters are: Plasma glucose (glucose oxidase method) and plasma insulin (Elisa Kit) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Haemodynamic parameters: Cardiac output, total peripheral resistance, index of contractility, heather index, thoracic fluid content, thoracic impedance, spectral analysis parameters, Baroreflex sensitivity; all parameters will be measured continuously starting with a 30 min baseline and continued after the OGTT for another 120 min using a Task Force Monitor (CNSystems) 2. Radial waveform parameters will be measured by applanation tonometry (AtCor) immediately after each blood sample, i.e. end of baseline, 30-, 60-, 90-, and 120 min post-drink 3. Indirect calorimety: Resting energy expenditure and respiratory quotient will be measured continuously starting 30 min before OGTT testing and 180 min thereafter by assessment of ventilation parameters using a ventilated hood system (COSMED) 4. Anthropometric parameters will assessed with a calibrated scale (Seca), and a statiometer (Seca) before the OGTT 5, Body composition parameters will be derived by either body impedance measurements (InBody 720) or deuterium oxide measurements (collection of saliva samples) before the OGTT 6. Questionnaire-derived data collected before the OGTT | — |
Countries
Switzerland
Outcome results
None listed