How common is lower back inflammation in patients with known inflammatory bowel disease such as Crohn’s disease and ulcerative colitis picked up on imaging for their bowel symptoms?

What proportion of patients with Inflammatory Bowel Disease have Axial Spondyloarthritis – An imaging referral strategy utilising Computed Tomography defined Sacroiliitis [Norfolk - Axial SPa Ibd REferral Computed Tomography Strategy (N-ASPIRE CT Strategy)]

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN11108086

Enrollment

Registered

2019-02-26

Start date

2019-08-01

Completion date

Unknown

Last updated

2023-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Axial Spondyloarthritis / Ankylosing Spondylitis, Spondyloarthritis, Rheumatology Musculoskeletal Diseases

Interventions

This is being undertaken as part of good clinical practice. Patients with a diagnosis of IBD who underwent a CT scan, and in whom there are suspicious features of axSpA will be invited to participate

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria for Phase 1 (postal survey): 1. CT scan performed for non-musculoskeletal indications 2. Age between 18 and 55 years old inclusive at the time of CT scan 3. Verified IBD diagnosis (by gastroenterologist via gastroenterology clinical letter +/- supportive histology/radiology results using electronic medical, lab, radiology records) 4. Presence of incidental Computer Tomographic defined Sacroiliitis (CTSI) which is defined as the presence of sacroiliac joint ankylosis or total erosion score (TES) of =3 or > 0.5 cm iliac sclerosis or > 0.3 cm sacral sclerosis Inclusion criteria for Phase 2 (clinical assessment): 1. Chronic back pain (> 3 months) 2. Onset of back pain before 45 years old 3. Including known/previous diagnosis of AS or axSpA (if unable to verify diagnosis retrospectively)

Exclusion criteria

Exclusion criteria: 1. Unable to tolerate MRI scanning (e.g. current history of claustrophobia) or contra-indication to MRI scanning (including but not limited to e.g. pacemaker, pregnancy, metallic or conducting foreign body, etc.) 2. Age 55 years 3. Lacking in capacity and/or unable to give informed consent 4. Unable to understand English to sufficient degree to be able to complete a questionnaire 5. Illiteracy 6. Prisoners 7. Unwilling to take part in the study

Design outcomes

Primary

Measure	Time frame
Proportion of Inflammatory Bowel Disease patients with incidental Computed Tomographic defined Sacroiliitis (CTSI) who have a rheumatologist-verified diagnosis of Axial Spondyloarthritis	—

Secondary

Measure	Time frame
1. Proportion of patients who fulfil the Assessment of Spondyloarthritis International Society (ASAS) classification criteria for Axial Spondyloarthritis 2. Proportion of symptomatic vs asymptomatic incidental CTSI	—

Countries

England, United Kingdom

Contacts

Public ContactChong Seng Edwin Lim

edwin.lim@nnuh.nhs.uk01603 647835

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026