The effect of magnesium sulfate on recurrence of rebound pain in patients undergoing regional anesthesia in the arm

The impact of perineural magnesium sulfate on rebound pain after supraclavicular brachial plexus block - randomized clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11083070

Enrollment

Registered

2022-12-22

Start date

2022-10-01

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of rebound pain in patients undergoing supraclavicular brachial plexus block for upper limb surgery. Surgery

Interventions

The sample size was calculated using STATA/IC v.17 (StataCorp, College Station, TX, USA) and also considering previous studies and potential exclusions from the protocols. The sample is 34, with 17 pa

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with ASA Physical Status classification I-lll; 2. Ability to understand and complete the pain diary; 3. Patients undergoing arm, forearm and hand surgery with indication for supraclavicular brachial plexus block without the association of another regional block or general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Severe heart disease; 2. Decompensated kidney disease; 3. Decompensated liver disease; 4. Severe respiratory failure; 5. Cognitive dysfunction that prevents cooperation with the study; 6. Calcium channel blocker treatment; 7. Confirmed coagulopathy; 8. Infection at the procedure location; 9. Illicit drug used 5 days ago; 10. Daily use of opioids more than 14 days before surgery; 11. Block failure; 12. Need to send to the intensive care unit (ICU) in the immediate postoperative period; 13. Neuropathy in the upper limb to be operated; 14. Allergy to local anesthetic, propofol or non-steroidal anti-inflammatory drugs; 15. Weight 35 kg/m²; 17. Chronic pain; 18. Pregnancy; 19. Need to change the anesthetic technique intraoperatively.

Design outcomes

Primary

Measure	Time frame
1. Pain measured by the Visual Numerical Scale (VNS) every 6 hours after the block for 24 hours 2. The time of block resolution, considered as the time when the first rescue analgesia was taken. However, in cases that didn’t require rescue analgesia, the time of block resolution will be considered when the patient reports the end of numbness or the end of heaviness in the blocked region.	—

Secondary

Measure	Time frame
Average cumulative opioid consumption in milligrams between the groups in the first 24 hours after the block, according to the doses taken and checked in the medical prescription.	—

Countries

Brazil

Contacts

Public ContactVictor Goulart

victor@roffor.com.br+55 92984151064

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026