URTI prevention in working people through ion air disinfection Not Applicable
Conditions
Interventions
The study design is an interventional, double-blind, randomized controlled trial at one center during the peak infection season in the fall/winter of 2022/23. Sample size n= 150. The randomization in
Sponsors
Paracelsus Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Adults 18-65 years old who have their workplace equipped with CUBUSAN air purification devices and dummy devices 2. Ability to exercise according to the Physical Activity Readiness Questionnaire (PAR-Q) as the basis for the Chester Step Test cardiorespiratory fitness survey
Exclusion criteria
Exclusion criteria: 1. Immunosuppression and genetic immunodeficiency disorders (primary immunodeficiency syndromes) 2. Immunodeficiency disorders 3. Severe respiratory disease requiring oxygen supplementation 4. Acute and untreated mental illnesses 5. Uncontrolled hypertension - systole = 180mmHg; diastole = 100mmHg 6. Active infectious diseases 7. Malignant neoplastic disease. No treatment within the last 5 years 8. Arteriosclerotic event 5mg/d prednisone, colchicine, imuran, methodrexate, azathioprine, cyclophosphamide, cyclosporine, or interferon preparations 12. Depression 13. Alcohol abuse, drug abuse, smoking > 20 cigarettes/day.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence and severity of URTIs measured using the Wisconsin Upper Respiratory Symptom Survey (WURSS-21) online each time a disease symptom occurs and until it has completely resolved | — |
Secondary
| Measure | Time frame |
|---|---|
| The following secondary outcomes will be measured bimonthly at each of the three timepoints (November 2022, January 2023 and March 2023) using questionnaires or the specified measurement instruments: 1. The workability of employees measured using the Work Ability Index (WAI) 2. Health-Related Quality of Life measured using 3 well-established questionnaires: 2.1. 12-Item Short Form Survey (SF-12) 2.2. Intercultural Quality of Life Comic (IQoLC) 2.3. The World Health Organisation- Five Well-Being Index (WHO-5) 3. Physical Activity Levels measured using the Physical Activity Level two-question (PAL-2Q) questionnaire 4. Current states of load and the states of recovery measured using the Recovery-Stress Questionnaires RESTQ-EBF The following four molecular surrogate parameters for infection and immunity are measured from saliva samples using Luminex-ELISA. Saliva samples will be taken bimonthly in November 2022, January 2023, and March 2023: 1. Salivary C-reactive protein (CRP) 2. Interleukin-6 (IL-6) 3. Interleukin-10 (IL-10) 4. Salivary Immunoglobulin A (sIgA) The following environmental parameters are measured at a one-time point at the end of the study: 1. Negative ions measured using the AiC2. The Air Ion Counter 2 is a handheld meter designed to measure ion density– the number of ions per cubic centimetre (ions/cc) in air. It measures this number separately for positive and negative ions (+ and – ions are usually present simultaneously). 2. Temperature, Relative Humidity, Carbon dioxide and air velocity measured with Testo 400 Universal Indoor Air Quality Instrument 3. The following particulate matter data PM1, PM2.5, PM4, PM10 and dCn (P/cm3) measured using Fidas Frog, a portable fine dust measurement device 4. PM0.3, LDSA and Number parameter measured using Partector 2 - Handheld Nanoparticle Detector 5. Airborne microbial contamination measured using the HYCON Airsampler and TSM agar strips for the determination of colony forming units (CFU) according to an | — |
Countries
Austria
Contacts
Public ContactArnulf Josef Hartl
Outcome results
None listed