COVID-19 (SARS-CoV-2 infection) Infections and Infestations COVID-19 (SARS-CoV-2 infection)
Conditions
Interventions
Upon enrolment, participants will complete an online questionnaire and provide a blood sample for antibody testing and swabs for viral testing. Thereafter, every two to four weeks participants will b
Sponsors
UK Health Security Agency
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Hospital healthcare worker willing to consent for regular follow up for 12 months with swabs and blood samples
Exclusion criteria
Exclusion criteria: Unwilling to participate in regular follow up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. SARS-CoV-2 antibody measured in NHS laboratories using local assays (Roche Cobas or Abbott Platforms) measured monthly 2. SARS-CoV-2 infection measured using PCR test using local assays measured every two weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Symptoms of SARS-Cov-2 infection measured by a 2 weekly survey of participants developed and validated by study team including the 12 most commonly reported symptoms 2. Ability to culture viable virus from SARS-CoV-2 residual viral samples that are PCR positive submitted to PHE throughout the study, cultured in category 3 laboratory on vero cells 3. Identification of reinfection or persistent infection if second positive test after 90 days measured using SARS-CoV-2 viral RNA submitted to COG-UK sequencing laboratories for each positive PCR result 4. Serological response measured using SARS-CoV-2 residual positive sera submitted to PHE and measured using laboratory assays monthly 5. Serological response measured using enzyme immunoassay detection of IgG measured using laboratory assays monthly 6. NHS Trust, age, sex, staff group, ethnicity and co-morbidities as recorded by the participant recorded at baseline using a novel questionnaire 7. Phylogenetic relatedness of SARS-CoV-2 whole genome sequences on positive PCR samples, linked to MRC CLIMB in a secure data infrastructure with other samples submitted from hospitals and community in the same time period | — |
Countries
England, United Kingdom
Contacts
Public ContactVictoria;Angela Hall;Dunne
;
Outcome results
None listed