Stroke in the young adult (>18 and <50 years old) Circulatory System
Conditions
Interventions
Potential participants (or, where necessary, a personal consultee) will be contacted by telephone by the participating site and the study explained. Interested participants will be sent a web link for
Sponsors
Keele University
Eligibility
Sex/Gender
All
Age
18 Years to 49 Years
Inclusion criteria
Inclusion criteria: 1. Aged >18 and under 50 years old PLUS one of the following: 1.1. For the first-ever ischaemic stroke, defined as: 1.1.1. Imaging positive (CT or MRI) acute ischaemic lesion. The lesion must correlate with clinical presentation OR 1.1.2. Clinical symptoms with appropriate changes on CT perfusion scanning that may subsequently reverse post appropriate treatment OR 1.1.3. Symptoms lasting less than 24 hours but with evidence of acute ischaemic change on imaging that matched clinical symptoms. 1.2. For haemorrhagic stroke: 1.2.1. Evidence of acute parenchymal intracerebral haemorrhage on CT/MRI imaging
Exclusion criteria
Exclusion criteria: Exclusion Criteria - previous stroke - sub dural, extra-dural or sub-arachnoid haemorrhage (unless primary presentation is ICH) - Stroke secondary to trauma - post surgical stroke - retinal artery occlusion - cerebral venous thrombosis (unless primary presentation is ICH)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The creation of a prediction model for ischaemic stroke recurrence and haemorrhagic stroke mortality in young stroke patients assessed through data collection on stroke recurrence and mortality, and measured using a multivariable prognostic model that will be internally and externally validated - timing will be based on median follow-up, the aim is for 5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Number and characteristics of patients successfully identified and recruited from multiple stroke centres across the UK, assessed through data collection on demographics and stroke, imaging and risk factor characteristics measured using descriptive statistics at baseline 2. Interaction effects between age, sex, and ethnicity on stroke-related risk factors, diagnostic investigations, and clinical outcomes measured using Chi-squared and Fisher Exact tests (if values <5) to compare categorical variables across groups. The Student t test will be used to compare means between groups, with the Mann-Whitney in instances where the data is not normally distributed at baseline 3. Recurrence, morbidity, and mortality due to stroke (or other vascular) specific risk factors assessed through data collection on time to recurrent stroke or other vascuar event, seizure and malignancy via creation of Kaplain Meier survival curves to measure cumulative incidences and fitting of cox regression models and hazard ratios calculated to estimate prognositc value of individual factors]; the timepoint is retrospective (2013-2020) and done at the point of contact so the reported time will be a mean follow up 4. Changes in life satisfaction and perceived ability to fulfil societal roles following stroke measured using the Fatigue Severity Scale and Stroke Impact Scale; the timepoint is retrospective (2013-2020) and done at the point of contact, so the reported time will be a mean follow-up | — |
Countries
England, United Kingdom
Contacts
Public ContactPhillip Ferdinand
Outcome results
None listed