Hepatitis C Infections and Infestations Hepatitis C
Conditions
Interventions
Participants are randomly allocated to one of two groups:
Group 1: Participants are treated using seveoflurane at a concentration of (1.0 ±0.2 MAC) as inhalation anesthestic with 100% oxygen for anes
Sponsors
Theodor bilharz insitute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 20-60 years 2. Hepatitis C virus positive 3. Grade A patients (Child-Pugh classification of liver disease) with liver enzymes below double fold of normal reference range 4. Scheduled for laparoscopic cholecystectomy surgery
Exclusion criteria
Exclusion criteria: 1. Grade B or C (Child-Pugh classification of liver disease) or with liver enzymes [alanine aminotransferase (ALT) or aspartate aminotransferase (AST) more than double fold of normal reference range 2. BMI over 30 3. Choronic renal disease and renalinsufficiency (creatinine>1,5 mg dl-1) 4. Use of alcohol or drugs 5. Diabetes Mellitus 6. Hypertenion 7. Unstable angina pectoris 8. History of myocardial infarction within the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Liver function is determined by measuring AST, ALT and alkaline phosphate in the blood postoperative, 1 day and 3 days postoperative 2. Kidney function is determined by measuring urea and creatinine in the blood postoperative, 1 day and 3 days postoperative | — |
Secondary
| Measure | Time frame |
|---|---|
| Hepatitis C viral RNA is measured using blood testing preoperative and 3 days postoperative. | — |
Countries
Egypt
Outcome results
None listed