Study on lung cancer screening in head and neck cancer patients using low-dose CT and chest x-ray

Lung Cancer Surveillance for Patients with Head and Neck Cancer (LCS-HNC)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10954990

Enrollment

200

Registered

2024-10-28

Start date

2015-09-01

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung metastasis or second primary lung cancer in head and neck cancer patients Cancer

Interventions

Participants will be randomly assigned to one of two groups: either chest radiography or low-dose computed tomography (LDCT) for lung cancer surveillance. Initial screening will occur at diagnosis, wi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Treatment naiïve patients diagnosed with HNSCC undergoing treatment with no prior lung cancer diagnoses or recent abnormal chest computed tomography (CT) findings

Exclusion criteria

Exclusion criteria: Patients with HNSCC aged 55 to 74 years with a smoking history of at least 30 pack-years, and who were currently smoking or had quit within during the past 15 years

Design outcomes

Primary

Measure	Time frame
Sensitivity and specificity of imaging methods (LDCT and CXR) for detecting lung metastases or second primary lung cancer, assessed using imaging analysis confirmed by biopsy in positive cases at baseline and 6- to 12-month follow-ups after treatment	—

Secondary

Measure	Time frame
Overall survival and disease-free survival measured using Kaplan-Meier survival analysis at 3 and 5 years	—

Countries

Canada

Contacts

Public ContactNaif Fnais

nfnais@ksu.edu.sa+1 (0)514 340 8246

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026