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The CAPNO trial: a randomized controlled trial of two different methods of carbon dioxide detection in preterm infants in the delivery room

The CAPNO trial: a randomized controlled trial of exhaled carbon dioxide monitoring in the preterm infant.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN10934870
Enrollment
60
Registered
2015-03-10
Start date
2014-08-01
Completion date
Unknown
Last updated
2020-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm birth Neonatal Diseases

Interventions

EtCO2 monitoring during resuscitation is the intervention being investigated in this trial. Consent will be obtained at the antenatal stage from mothers who are expecting to deliver at less than 32 we

Sponsors

Cork University Maternity Hospital Neonatology Dept
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: All mothers expected to have a preterm delivery of less than 32 weeks gestation will be approached for antenatal consent.

Exclusion criteria

Exclusion criteria: 1. Mothers presenting with oligohydramnios (amniotic fluid index <5), suspected hypoplasia of the lungs and any known congenital anomalies of the fetus. 2. Failure to obtain consent.

Design outcomes

Primary

MeasureTime frame
A reduction in the combined percentage of hypocapnia and hypercapnia within the first two hours of life, as measured by on blood gas analysis completed in the NICU

Secondary

MeasureTime frame
1. Heart rate via ECG and oxygen saturation (SpO2) at several 1 minute intervals, in the first few minutes of life 2. EtCO2 values for several 1 minute intervals in infants who were randomised to receive capnography, in the first few minutes of life 3. Completion and occurrences of resuscitation procedures via retrospective analysis of video recordings consented, by parents of the infant, to be obtained during the resuscitation 4. Analysis of the occurrence of intra ventricular haemorrhages (IVH), necrotising enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP)

Countries

Ireland

Contacts

Public ContactEugene Dempsey

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 11, 2026