Can a mechanically controlled compression of the upper lip reduce the perception of pain during a local anesthetic injection in the mouth?

Effect of upper lip compression on pain control during local maxillary anesthesia. A Split-mouth randomized clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10930940

Enrollment

Registered

2020-01-02

Start date

2016-04-01

Completion date

Unknown

Last updated

2020-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Local maxillary anesthetic injection Oral Health

Interventions

To determine the chronological order of the injection for to control the measurement bias and placebo effect of lip compression, a randomization process within subject was performed using software ava

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years or older 2. Signed informed consent form

Exclusion criteria

Exclusion criteria: 1. History of allergies or adverse reactions to local anesthesia 2. Presence of dental pain because of dental or orthodontic treatment one month prior to the study 3. Infection in the puncture area 4. Pharmacological treatment with non-steroidal anti-inflammatory drugs (NSAIDs), benzodiazepines or antidepressants

Design outcomes

Primary

Measure	Time frame
The level of pain perceived by the volunteer on the Visual Analogue Scale (VAS) during the anesthetic injection recorded at the time of injection	—

Secondary

Measure	Time frame
Covariance of the main outcome (pain perception during anaesthetic injection) according to variables such as sex and age of participants.	—

Countries

Chile

Contacts

Public ContactPedro Aravena

paravena@uach.cl+56 632221205

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026